Abstract
MACC1 gene is a newly discovered gene and plays an important role in the metastasis of colorectal cancer (CRC). The objective of this study was to investigate whether MACC1 is an independent factor associated with lymphatic metastasis in CRC patients. We analyzed the association between MACC1 expression and lymphatic metastasis in a nested case-control study including 99 cases and 198 matched controls in CRC patients, assessed from August 2001 to March 2015. Cases were defined as lymphatic metastasis and non-lymphatic metastasis according to AJCC TNM stages; for each case, two age-matched control without lymphatic and distant metastasis was randomly selected from the study participants. Demographic, variables about metastasis and MACC1 expression were collected. In multivariate analysis, the OR (95% CI) of MACC1 expression was 1.5 (1.1 to 2.0) in patients with lymphatic metastasis versus non-lymphatic metastasis after adjusting all variables. After adjustment for all variables and age stratification, MACC1 expression was found to be an independent risk factor for lymph node metastasis in the middle-aged group (OR 2.1, 95%CI 1.1-4.0). A nonlinear relationship between MACC1 expression and 64-75 age group was observed. The probability of metastasis slightly increased with the MACC1 level lower than turning point 1.4. At the same time, the probability of lymphatic metastasis was obviously increased even after adjusting all variables when MACC1 level higher than 1.4 (OR 11.2, 95% CI 1.5-81.5; p = 0.017) in the middle age group. The expression of MACC1 was not associated with lymphatic metastasis in populations younger than 64 or older than 75. The results demonstrates that increased MACC1 level in 64-75 age group might be associated with lymphatic metastasis in CRC patients.
Highlights
Colorectal cancer (CRC) is a common malignant tumor that seriously threatens human life and health
We aimed to evaluate the association between Metastasis-associated in colon cancer1 (MACC1) expression and lymphatic metastasis in colorectal cancer (CRC) based on TGCA samples and to determine whether MACC1 is an independent predictor of lymphatic metastasis in patients with CRC
We analyzed the independent effect of MACC1 expression on lymphatic metastasis; after trisecting the MACC1 expression levels, we found that MACC1 was not associated with lymphatic metastasis (Table 5)
Summary
Colorectal cancer (CRC) is a common malignant tumor that seriously threatens human life and health. With the improvement of people’s living standards, especially the change of dietary structure, the incidence and mortality of CRC have increased year by year [1]. Metastasis is an important cause of death in patients with CRC. MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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