Abstract
Background: Lipoma preferred partner (LPP) and T-cell activation Rho GTPase activating protein (TAGAP) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms. Results: This meta-analysis included the same 7 studies for LPP rs1464510 and TAGAP rs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22–1.30) and 1.17 (95% CI: 1.14–1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects. Conclusions: This meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease.
Highlights
Celiac disease (CD) is a chronic and immune-mediated enteropathy that is induced by dietary protein gluten in genetically predisposed individuals [1]
The ineligible records consisted of seventeen other studies, one animal study, three review articles, three family studies, six meeting articles, one meta-analysis of inflammatory bowel disease, two studies without the target SNPs, and six studies aimed at other immune diseases
Our meta-analysis suggests that both Lipoma preferred partner (LPP) rs1464510 and T-cell activation Rho GTPase activating protein (TAGAP) rs1738074 polymorphisms contribute to the susceptibility to CD in European and American
Summary
Celiac disease (CD) is a chronic and immune-mediated enteropathy that is induced by dietary protein gluten (from wheat, barley and rye) in genetically predisposed individuals [1]. It is a small-intestine disorder, affecting approximately 1% of the European population with some regional. Lipoma preferred partner (LPP) and T-cell activation Rho GTPase activating protein (TAGAP) polymorphisms might influence the susceptibility to celiac disease. We performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms
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