Association of Lower Plasma Fetuin-A Levels With Peripheral Arterial Disease in Type 2 Diabetes

Abstract

In the article by Eraso et al. (1), circulating fetuin-A was lower in subjects with type 2 diabetes and an ankle brachial index (ABI) <0.9 compared with individuals with higher ABI. Furthermore, in an unadjusted model circulating fetuin-A correlated positively with ABI. It was concluded that low circulating fetuin-A may serve as a biomarker of peripheral arterial disease (PAD). This conclusion is only weakly supported by the data. It is very important to know that in the study by Eraso et al. (1), subjects with any clinical evidence of cardiovascular disease (CVD) were excluded. Considering that …