Abstract
Vascular dysfunction and hyperlipidemia are essential risk factors contributing to essential hypertension (EH). The plasmacytoma variant translocation 1 (PVT1) is involved in modulating angiogenesis in tumor tissues and plays an important role in fat differentiation in the progress of obesity. Therefore, we selected two tagSNPs of PVT1 (rs10956390 and rs80177647) to investigate whether they are contributing to the risk of hypertension in Chinese patients. In total, 524 adult patients with EH and 439 matched healthy controls were enrolled for two central of China. Results. PVT1 rs10956390 and rs80177647 polymorphisms were genotyped by using TaqMan assay. PVT1 rs10956390 TT genotype was associated with a decreased risk of EH (OR = 0.561, 95% CI = 0.372-0.846, P = 0.006), while rs80177647 TA genotype was associated with an increased risk (OR = 2.236, 95% CI = 1.515-3.301, P < 0.001). Rs10956390 T allele was associated with lower triglyceride levels in the plasma both from healthy and EH donors. What is more, there is an association between rs10956390 polymorphism and HDL-C level, as well as LDL-C. Conclusion. PVT1 rs10956390 and rs80177647 polymorphisms may contribute to the risk of EH in Chinese population by regulating blood lipid levels.
Highlights
Essential hypertension (EH), a noninfectious multifactorial disease, is a crucial risk factor for the morbidity and mortality of cardiovascular disease worldwide [1]
Zheng et al revealed that plasmacytoma variant translocation 1 (PVT1) orchestrates the angiogenesis of vascular endothelial cells by evoking connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2) expression in a miR-26b dependent manner [14]
We found that the polymorphisms of the two SNPs of PVT1 were associated with the risk of EH
Summary
Essential hypertension (EH), a noninfectious multifactorial disease, is a crucial risk factor for the morbidity and mortality of cardiovascular disease worldwide [1]. After long-time defined as “gene desert” for a long time, it has been recognized that lncRNAs play a pivotal role in diseases including cardiovascular diseases in a delicate and sophisticated network modulation manner [3,4,5,6]. Zheng et al revealed that PVT1 orchestrates the angiogenesis of vascular endothelial cells by evoking connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2) expression in a miR-26b dependent manner [14]. Sun et al found that PVT1 reduces the expression of miR-190a-5p in vascular endothelial cells (ECs), resulting in proliferation [15]. Guo et al unraveled that PVT1 knockdown ameliorates ox-LDL-induced vascular endothelial cell injury and atherosclerosis through the miR-153-3p/GRB2 axis [16].
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