Abstract
The worldwide incidence of hepatocellular carcinoma (HCC), the major histological type of primary liver cancer, is heterogeneous due to the variable prevalence of etiological factors, indicating a correlation of HCC risk with genetic variations among individuals. Among long non-coding RNAs (lncRNAs) located in the chromosome 8q24 loci and involved in the carcinogenesis are colon cancer associated transcript 2 (CCAT2) and cancer susceptibility candidate 8 (CASC8). In this study, the association of CCAT2 and CASC8 gene polymorphisms with the occurrence of HCC was explored between 397 HCC patients and 1195 controls. We found that carriers of rs6983267 GG in CCAT2 were more susceptible to HCC, with the odds ratio (OR) and adjusted odds ratio (AOR) being 1.532 (95% CI, 1.103–2.129; p = 0.011) and 1.627 (95% CI, 1.120–2.265; p = 0.033), respectively. Moreover, for patients stratified by age (under 65), gender (male only), or status of drinking (habitual drinkers), a protective effect of CASC8 rs3843549 on presenting high Child–Pugh scores, metastatic vascular invasion, or large-size tumors was observed in a dominant model. Collectively, our data reveal association of CCAT2 and CASC8 gene polymorphisms with the occurrence and progression of HCC.
Highlights
Hepatocellular carcinoma (HCC), the major histological type of primary liver cancer, is the sixth most frequent type of malignancies with a steep death rate [1] and a highly heterogeneous global prevalence [2]
We observed that individuals who are positive for HBV surface antigen (HBsAg) and anti-HCV, or habitually drinking alcohol had increased susceptibility to hepatocellular carcinoma (HCC)
Our data show the complexity of long non-coding RNAs (lncRNAs) cancer associated transcript 2 (CCAT2) and cancer susceptibility candidate 8 (CASC8) gene variations within the 8q24 region in orchestrating hepatocarcinogenesis
Summary
Hepatocellular carcinoma (HCC), the major histological type of primary liver cancer, is the sixth most frequent type of malignancies with a steep death rate [1] and a highly heterogeneous global prevalence [2]. Most HCC develops in subjects with a background of established hepatic conditions [3], numerous risk factors, such as exposure to iron overload, prolonged infection with hepatitis B or C virus (HBV or HCV), use of excess tobacco and alcohol, and aflatoxin B [4,5], are known to contribute to the complex process of liver tumorigenesis. Findings of numerous studies have indicated that single-nucleotide polymorphisms (SNPs) alone or jointly with other. Res. Public Health 2019, 16, 2833; doi:10.3390/ijerph16162833 www.mdpi.com/journal/ijerph
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
