ASSOCIATION OF LIPID PROFILE WITH BODY MASS INDEX IN GALL STONE DISEASE

Abstract

Introduction: Gall stone disease is common in northern regions of India including Uttarakhand. It is traditionally seen in fat, fertile, female of fourty. Apart from this, age, obesity, hyperlipidemia, smoking & diabetes are other risk factors. Gall stones show more association with elevated levels of triglyceride and low high density lipoprotein (HDL-C) where less association with total cholesterol and low density lipoprotein (LDL-C). Increased prevalence of gall stone reported in overweight. This present study conducted with an aim to find out the co-relation of lipid profile, BMI (body mass index) and gall stones in Uttarakhand population attending Shridev Suman Subharti Medical College Teaching Hospital, Dehradun.
 Material & Methods: Total 120 patients (10 M, 110 F) were included in the study following confirmation of diagnosis of gall stones on ultrasound. Age, sex, dietary habits, occupation, medical history and drug history of each patient were recorded in predesigned, tested proforma. The BMI calculated as weight in Kg/height in meter square. BMI of 18 to 24.9 were regarded as normal, whereas, 25 to 29.9 as overweight, 30 to 39.9 as obese and above 40 as morbid obese. The serum cholesterol, LDL, HDL and Triglyceride were estimated on a fasting sample by keeping patient nil orally for 12hrs after their normal meal.
 Results: Out of total 120 patients, 110(91.67%) were female & 10(8.33%) were male, with female to male ratio 9:1. The age-group of 21 to 40 years was the most common, with 64(53.33%) patients belonging to this group. Triglyceride was raised in 35(29.17%) patients, total cholesterol was raised in 7(5.83%) patients and LDL was raised in 5(4.17%) patients. The cholesterol was lowered in 13(10.83%) patients, HDL was lowered in 8(6.66%) patients and triglyceride was lowered in 3(2.5%) patients. Triglyceride & LDL were raised in 4(3.3%) patients, cholesterol and triglyceride were raised in 3(2.5%) patients and cholesterol and HDL were lowered in 4 (3.33%) patients. Patients with BMI of 18.0-24.9 were 72(60.00%), BMI of 25-29.9 were 36(30.00%) and BMI of 30-39.9 were 9(7.50%) respectively.
 Conclusion: The present study on presence of Gall stones which are more commonly found in females aged 21 to 40 years. Raised levels of Triglyceride and lower levels of cholesterol are associated with gall stones. There is no association between Increased BMI & presence of gall stones. BMI is associated with higher level of Triglyceride.
 Key Words: Gall stone, BMI, Triglyceride, Cholesterol, and HDL-C.