Abstract
BackgroundLimited studies regarding the correlation of lipid accumulation product (LAP) with a decreased estimated glomerular filtration rate (eGFR) have yielded conflicting findings, and no report has demonstrated the relationship of LAP with chronic kidney disease (CKD), defined as the presence of albuminuria and/or a decreased eGFR. The purpose of this study was to estimate the possible correlation of LAP with CKD prevalence in Chinese community adults.MethodIn this cross-sectional study, LAP level of 7202 participants (age ≥ 40 years) was determined, and its possible association with CKD was evaluated by a multiple logistic regression model.ResultsCompared with subjects with non-CKD, non-albuminuria, and high eGFR, LAP levels significantly increased in female not male subjects with CKD, albuminuria, and low eGFR, respectively (all P < 0.001). The univariate logistic regression analysis revealed that LAP level of female not male subjects were significantly and positively associated with the prevalence of CKD (P < 0.001). The multivariate logistic regression analysis showed that the risk of CKD prevalence in female not male subjects progressively increased across LAP quartiles (P for trend < 0.01), and the risk of CKD prevalence of subjects in Q4 significantly increased compared to those in Q1 after adjustment for potential confounding factors in Models 4 (odds ratio [OR]: 1.382, 95% confidence intervals [CI] 1.002–1.906, P < 0.05). Stratified analysis revealed positive associations of LAP quartiles with risk of CKD prevalence in people with the following characteristics: women, older, overweight, with hypertension, normal glucose tolerance, appropriate low-density lipoprotein cholesterol, nonsmokers, nondrinkers, and no cardiovascular disease events.ConclusionsHigh LAP levels might be significantly associated with risk of CKD prevalence in community-dwelling Chinese female adults, which may inform both public health recommendations and clinical practice.
Highlights
Limited studies regarding the correlation of lipid accumulation product (LAP) with a decreased estimated glomerular filtration rate have yielded conflicting findings, and no report has demonstrated the relationship of LAP with chronic kidney disease (CKD), defined as the presence of albuminuria and/or a decreased eGFR
Univariate analysis of variables contributing to CKD prevalence The prevalence of CKD showed a significantly positive correlation with age, blood pressure, total cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C), serum Cr, urinary albumin–creatinine ratio (ACR), prevalence of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) events, and use of hypoglycaemic drugs, but the correlation between CKD prevalence and eGFR was negative in male subjects (P < 0.001 or P < 0.01 or P < 0.05; Table 2)
The logistic regression analysis revealed that LAP level of female not male subjects were significantly and positively associated with CKD prevalence, and the risk of CKD prevalence in female not male subjects progressively increased across LAP quartiles after adjustment for potential confounding factors
Summary
Limited studies regarding the correlation of lipid accumulation product (LAP) with a decreased estimated glomerular filtration rate (eGFR) have yielded conflicting findings, and no report has demonstrated the relationship of LAP with chronic kidney disease (CKD), defined as the presence of albuminuria and/or a decreased eGFR. The purpose of this study was to estimate the possible correlation of LAP with CKD prevalence in Chinese community adults. Compelling data indicate that obesity, especially central obesity, is involved in the development and progression of CKD and its components, including a high urinary albumin–creatinine ratio (ACR) of ≥30 mg/g, called albuminuria, and a low estimated glomerular filtration rate (eGFR) of < 60 mL/min/1.73 m2 [5,6,7,8], but the mechanisms underlying the associations are multifactorial and still unclear.
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