Abstract
BackgroundLipid accumulation product (LAP) is an index describing the overaccumulation of lipid. Baseline LAP was used for type 2 diabetes (T2D) prediction in previous studies. But the longitudinal trajectories of LAP, which reflect the efficacy of patients’ lipid-lowering treatment and lifestyle improvement, have rarely been studied. The aim of this study is to explore the association of lipid accumulation product trajectories with 5-year incidence of type 2 diabetes.MethodsThis cohort study included 4508 non-diabetic participants with a median age of 42 years. Using the group-based trajectory modeling (GBTM), LAP from 2011 to 2016 were determined and identified as three trajectories: low (n = 3639), moderate (n = 800), and high (n = 69). Baseline LAP was divided into groups by percentiles and tertiles respectively for the comparison of LAP trajectories. The associations between 5-year T2D incidence and LAP trajectories and baseline LAP were both assessed by generalized linear models.ResultsFrom 2011 to 2016, 169 participants developed T2D (the 5-year incidence of 3.8%). For participants with low, moderate, and high trajectories, the incidence of T2D was 2.1, 10.0, and 15.9%, respectively. A significant trend was observed in the relative risks (RRs) of 5-year incident T2D in participants with moderate (RR, 1.95; 95% CI: 1.41–2.70) and high LAP trajectory (RR, 2.20; 95% CI: 1.12–4.30) in the fully adjusted model (p for trend< 0.001). However, there were no statically significant trends in RRs in different tertiles of baseline LAP found after full adjustments.ConclusionThe trajectories of LAP has an independent effect on 5-year T2D incidence beyond LAP measured at baseline.
Highlights
Lipid accumulation product (LAP) is an index describing the overaccumulation of lipid
T2D was defined by the presence of any of the following: 1) self-reported doctor-diagnosed type 2 diabetes, 2) current use of insulin or oral hypoglycemic agents, and 3) fasting blood glucose ≥7.0 mmol/L [24]
In the current cohort study, we found that higher LAP trajectories were associated with an increased risk of diabetes
Summary
Lipid accumulation product (LAP) is an index describing the overaccumulation of lipid. The aim of this study is to explore the association of lipid accumulation product trajectories with 5-year incidence of type 2 diabetes. Lipid accumulation product (LAP) which calculated by waist circumference (WC) and fasting triglycerides (TG) concentration is proposed to describe lipid overaccumulation [9] and has been found higher in diabetic patients [10, 11]. Studies revealed that LAP had the potentials to predicting the risk of diseases such as cardiovascular disease (CVD) [12,13,14], non-alcoholic fatty liver disease [15] and metabolic syndrome [16, 17] in some healthy populations. LAP had been proved to be a strong predictor of diabetes occurrence in non-diabetic populations [18, 19].
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