Abstract
Background Female adolescents are considered a risk group for cardiometabolic disease due to their lifestyle (LS). Objective To evaluate the association between LS classes and body composition groups with cardiometabolic disease risk factors and pro- and anti-inflammatory biomarkers in female adolescents. Methods This cross-sectional study was carried out with female adolescents aged 14 to 19 years, from Viçosa-MG, Brazil. Latent class analysis assessed LS classes. Kinanthropometric measurements were taken together with the body fat percentage (BF%), being analyzed by the Dual Energy X-ray Absorptiometry (DEXA) equipment. Blood pressure and biochemical parameters were analyzed in the Health Division of the Federal University of Viçosa. The pro- and anti-inflammatory biomarkers were analyzed using Luminex technology. Associations with biomarkers were estimated by multiple linear regression. Results 405 female adolescents were evaluated. The majority, 82.57%, 72.90%, and 65.31%, were classified as inactive by the number of steps, with high screen and cell phone time, respectively. Furthermore, 41.55% did meet the minimum of 60 minutes of moderate-to-vigorous physical activity (MVPA) and 54.69% had high values of BF% (DEXA). The “Sedentary & Inactive LS” class together with the high levels of weight and BF% were associated with increased levels of blood pressure, lipid profile, and uric acid. It was also found that “Inactive & Sedentary LS”, high BF%, insulin resistance, and ultra-sensitive C-reactive protein were associated with the concentrations of proinflammatory biomarkers of tumor necrosis factor-α, interleukin-6, and leptin. Conclusion We concluded that female adolescents with overweight/obese and high BF% presented higher values of anthropometric indicators, levels of blood pressure, concentration of uric acid and hs-CRP, and lower concentration of HDL. Inactive and Sedentary lifestyle of these girls, along with excess body fat, insulin resistance, and higher concentrations of hs-CRP were associated with the higher concentration proinflammatory markers.
Highlights
Adolescence is one of the critical moments in life when most behaviors related to lifestyle (LS) are established and can exert influence in adulthood [1]
This study evaluated the association between lifestyle and body composition with risk factors for cardiometabolic diseases and pro (TNF-α, IL6, and Leptin) and anti (IL-10) inflammatory biomarkers in female adolescents
This study can help educators and health professionals in designing more efficient strategies to encourage female adolescents to adopt a more active lifestyle, less sedentary behaviors, with healthy and balanced diets, aiming at controlling excess weight and body fat. These healthy behaviors may prevent the manifestation of risk factors for cardiometabolic diseases and inflammatory markers, whose early onset in adolescence may worsen in adulthood, triggering cardiovascular diseases
Summary
Adolescence is one of the critical moments in life when most behaviors related to lifestyle (LS) are established and can exert influence in adulthood [1] In this sense, the promotion of a healthy LS among adolescents should be the target of interventions, since several of the modifiable behavioral risk factors, such as physical inactivity, excessive sedentary. To evaluate the association between LS classes and body composition groups with cardiometabolic disease risk factors and pro- and anti-inflammatory biomarkers in female adolescents. We concluded that female adolescents with overweight/obese and high BF% presented higher values of anthropometric indicators, levels of blood pressure, concentration of uric acid and hs-CRP, and lower concentration of HDL. Inactive and Sedentary lifestyle of these girls, along with excess body fat, insulin resistance, and higher concentrations of hs-CRP were associated with the higher concentration proinflammatory markers
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