Abstract
BackgroundKlotho, possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). The present study was carried out aiming to investigate the association of Klotho-rs564481 (C1818T) gene polymorphism with hypertension and CAD.MethodsA total of 286 CAD-suspicious subjects were entered into this case-control study. The polymorphism was investigated in hypertensive patients with no CAD (H-Tens, n = 60); hypertensive patients with CAD (CAD + H-Tens, n = 95); CAD patients with no hypertension (CAD, n = 61); and non-hypertensive non-CAD subjects, which were regarded as the control group (Ctrl, n = 70). Genotype and allele frequencies were assessed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.ResultsA significant difference was found in allele frequency of Klotho C1818T among the four research groups (P = 0.03). It was also found that wild-type homozygote subjects were negatively associated with hypertension as compared to heterozygote ones (OR = 0.07 [95% CI: 0.008–0.69] P = 0.02). Moreover, in the subgroups older than 57 years old, dominant genetic model demonstrated a negative association with CAD combined with hypertension (OR = 0.31 [95% CI: 0.10–0.95] P = 0.04).ConclusionsIn conclusion, Klotho C1818T variant may be associated with a decreased risk of hypertension. Moreover, aging enhanced positive effects of the Klotho polymorphism on CAD combined with hypertension, indicating the possibility that the KLOTHO gene might play a part in the age-related occurrence of CAD combined with hypertension.
Highlights
Klotho, possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD)
Results of multinomial regression models Results of multinomial regression model, applied for further data analysis by adjusting for age, sex, Body mass index (BMI), and Cr are presented in Table 3, indicating that Klotho C1818T homozygotes type was a significant predictor of hypertension in the all-subjects category
In subjects younger than 57 years, neither in recessive model nor in dominant model was a significant association observed between the Klotho C1818T variant and the risk of CAD, hypertension, and CAD combined with hypertension
Summary
Possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). The present study was carried out aiming to investigate the association of Klotho-rs564481 (C1818T) gene polymorphism with hypertension and CAD. Ample evidence has revealed that the metabolic, genetic, and environmental factors are involved in susceptibility to CAD and hypertension [8, 9]. Recent advances in disease biology and understanding of their molecular mechanisms have led to reporting various susceptible genes involved in incidence of these diseases. In this regard, identification of these genes along with environmental factors is essentially important [10, 11]
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