Abstract
Background: The type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Several variants may contribute s ignificantly to the risk of type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys). In this study, we evaluated the association of Pro1 2Ala variant of the peroxisome proliferatoractivated receptor-γ and the Glu23Lys variant of the ATP-sensitive potassium channel, Kir6.2 (KCNJ11) with the type 2 diabetes in Korean population. Method: This study included 331 subjects consisting of 172 patients wi th type 2 diabetes and 159 nondiabetic control subjects enrolled from the Kyungpook, Keimyung and Catholic university hospital in Daegu, Korea. We genotyped Kir6.2 (Glu23Lys) and PPARγ (Pro12Ala) polymorphism and examined their association with the type 2 diabetes. Result: In the separate analyses, the Kir6.2 Glu23Lys (P = 0.385) and the PPARγ Pro12Ala (P = 0.191) polymorphism showed no significant association with type 2 diab etes. In addition, the results of our study showed no evidence of a synergistic interaction between Kir6.2 and PPARγ gene in each group (P = 0.110, P = 0.276). Conclusion: In this study, no association was seen between the genetic polymorphisms of Kir6.2, PPARγ and type 2 diabetes. However, to clarify whether genetic polymorphisms of these genes contribute to the development of type 2 diabetes, further studies involving larger Korean populations may be needed. (J Kor Diabetes Assoc 31:455~464, 2007)
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