Abstract
KIF6 is a class of molecular motor from the kinesin superfamily. Recently, multiple large studies consisting mainly of Europeans have shown that KIF6 Trp719Arg SNP may be a new predictive factor for coronary artery disease (CAD) event risk. The allelic frequency distribution of rs20455 is different in various populations, yet studies among the Han population, one of the largest ethnic groups in the World, have not been conducted. This study is aimed to evaluate the association of KIF6 Trp719Arg variant with angiographic CAD and serum lipid levels in the Han population from northern China. In this case-controlled study, peripheral blood samples were collected from 356 patients and 568 controls of Han Chinese origin. Genotyping was performed by a high-resolution melting curve. The impact of rs20455 on CAD and non-fatal MI was evaluated in a dominant genetic model with stepwise multiple regression analysis. There were no significant differences of genotypes and allele frequency between angiographic CAD and control groups (p > 0.05); however, that of MI and non-MI subgroups were significant differences (p < 0.05). After adjusting for significant risk factors, angiographic CAD risk was not significantly increased in 719Arg allele carriers compared with non-carriers. Further analysis revealed that the non-fatal MI risk and triglyceride levels were significantly higher in 719Arg allele carriers than non-carriers. In conclusion, KIF6 719Arg allele was not an independent risk factor for angiographic CAD susceptibility in Han populations from northern China. However, it was associated with a significantly higher TG level, which may indicate an increased myocardial infarction risk in angiographic CAD patients.
Highlights
Coronary artery disease (CAD) is influenced by both environmental and genetic factors [1,2]
Only chromosome 9p21 is associated with CAD risk in the Chinese Han population, with the carriers having a 30% increased risk of CAD compared with non-carriers [5]
Relevant baseline clinical characteristics and traditional risk factors of the participants are shown in CAD cases versus controls
Summary
Coronary artery disease (CAD) is influenced by both environmental and genetic factors [1,2]. Only chromosome 9p21 is associated with CAD risk in the Chinese Han population, with the carriers having a 30% increased risk of CAD compared with non-carriers [5]. Kinesin-Like Protein 6 (KIF6) is a new candidate gene for CAD which was first identified in 2007 as a potential risk factor in European populations [6]. It is a class of homodimeric molecules involved in intracellular microtubule transportation and is ubiquitously expressed in coronary arteries and other vascular tissue [7]. No studies have yet reported a link between KIF6 and CHD events in the Chinese
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