Abstract
BackgroundSeveral genome-wide association studies have discovered novel loci at chromosome 12q24, which includes mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cbIB type (MMAB), and potassium channel tetramerization domain-containing 10 (KCTD10), all of which influence HDL-cholesterol concentrations. However, there are few reports on the associations between these polymorphisms and HDL-C concentrations in Chinese population. This study aimed to evaluate the associations between functional polymorphisms in three genes (MVK, MMAB and KCTD10) and HDL-C concentrations, as well as coronary heart disease (CHD) susceptibility in Chinese individuals.MethodsWe systematically selected and genotyped 18 potentially functional polymorphisms in MVK, MMAB and KCTD10 by using the TaqMan OpenArray Genotyping System in a Chinese population including 399 dyslipidemia cases, 697 CHD cases and 465 controls. Multivariate logistic regression analyses were performed to estimate the relationship between the genotypes and dyslipidemia, CHD risk with adjustment of relevant confounders.ResultsAmong six polymorphisms showing significant associations with dyslipidemia, the minor alleles of rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB were significantly associated with a decreased risk of CHD (additive model: OR = 0.71, 95 % CI = 0.53–0.97, P = 0.029 for rs11066782; OR = 0.73, 95 % CI = 0.54–0.99, P = 0.044 for rs11613718 and OR = 0.57, 95 % CI = 0.40–0.80, P = 0.001 for rs11067233). Further combined analysis showed that individuals carrying “3-4” favorable alleles presented a 62 % (OR = 0.38, 95 % CI = 0.21–0.66) decreased risk of CHD compared with those carrying “0–2” favorable alleles.ConclusionsThese findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of CHD by altering plasma HDL-C levels in Han Chinese.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-016-0348-7) contains supplementary material, which is available to authorized users.
Highlights
Several genome-wide association studies have discovered novel loci at chromosome 12q24, which includes mevalonate kinase (MVK), methylmalonic aciduria cbIB type (MMAB), and potassium channel tetramerization domain-containing 10 (KCTD10), all of which influence HDL-cholesterol concentrations
Association analyses for plasma lipid concentrations We examined the effect of these six loci on plasma total cholesterol (TC), TG, or high-density lipoprotein-cholesterol (HDL-C) concentrations, respectively, using a linear
In this study, we investigated the relationship of 17 Single nucleotide polymorphism (SNP) located in three genes (MVK, MMAB and KCTD10) with HDL-C concentrations and coronary heart disease (CHD) risk in a Chinese population
Summary
Several genome-wide association studies have discovered novel loci at chromosome 12q24, which includes mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cbIB type (MMAB), and potassium channel tetramerization domain-containing 10 (KCTD10), all of which influence HDL-cholesterol concentrations. In 2008, a genome-wide association study (GWAS) conducted in populations of European descent discovered novel loci at chromosome 12q24, which includes mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cbIB type (MMAB), and potassium channel tetramerization domain-containing 10 (KCTD10), all of which influence HDL-C concentrations [13]. This association has been consistently replicated in the subsequent studies [14,15,16]. MVK, MMAB and KCTD10 genes may be candidates as susceptibility genes modulating HDL-C concentrations and affect the risk of dyslipidemia and CHD
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