Abstract
BackgroundIn our previous study, we had assessed in the Chinese Han population the association of KCNB1 rs1051295 with metabolic traits indicating metabolic syndrome, and showed that KCNB1 rs1051295 genotype TT was associated with increase of waist to hip ratio (WHR), fasting insulin (FINS), triglycerides (TG) and decreased insulin sensitivity at basal condition. Here, we aimed at detecting whether there were associations between other tag SNPs of KCNB1 and favorable or unfavorable metabolic traits.MethodsWe conducted a case–control design of population-based cross-sectional study to investigate the association between each of the 22 candidates tag SNPs of KCNB1 and metabolic traits in a population of 733 Chinese Han individuals. The association was assessed by multiple linear regression analysis or unconditional logistic regression analysis.ResultsWe found that among the 22 selected tag SNPs, four were associated with an increase (rs3331, rs16994565) or decrease (rs237460, rs802950) in serum cholesterol levels; two of these (rs237460, rs802590) further associated or were associated with reduced serum LDL-cholesterol. Two novel tag SNPs (rs926672, rs1051295) were associated with increased serum TG levels. We also showed that KCNB1 rs926672 associated with insulin resistance by a case–control study, and two tag SNPs (rs2057077and rs4810952) of KCNB1 were associated with the measure of insulin resistance (HOMA-IR) in a cross-section study.ConclusionThese results indicate that KCNB1 is likely associated with metabolic traits that may either predispose or protect from progression to metabolic syndrome. This study provides initial evidence that the gene variants of KCNB1, encoding Kv2.1 channel, is associated with perturbation of lipid metabolism and insulin resistance in Chinese Han population.
Highlights
In our previous study, we had assessed in the Chinese Han population the association of KCNB1 rs1051295 with metabolic traits indicating metabolic syndrome, and showed that KCNB1 rs1051295 genotype TT was associated with increase of waist to hip ratio (WHR), fasting insulin (FINS), triglycerides (TG) and decreased insulin sensitivity at basal condition
Genotype AT was associated with increased total cholesterol (TC) levels (P = 0.049, b = 0.16(0.00, 0.32)), insulin resistance (P = 0.03, b = 0.74(0.06, 1.42)), and fasting insulin (FINS) (P = 0.02, b = 0.10 (0.01, 0.19)) compared with genotype TT, and showed a trend in increasing islet β-cell function by homeostasis model assessment (HOMA)-B% (P = 0.09, b = 5.66(-0.86, 12.18)) (Table 1)
We showed KCNB1 rs926672 associated with insulin resistance by a case–control study, and two tag Single-nucleotide polymorphisms (SNP) of KCNB1 were associated with the measure of insulin resistance as determined by HOMA-IR in a cross-section study
Summary
We had assessed in the Chinese Han population the association of KCNB1 rs1051295 with metabolic traits indicating metabolic syndrome, and showed that KCNB1 rs1051295 genotype TT was associated with increase of waist to hip ratio (WHR), fasting insulin (FINS), triglycerides (TG) and decreased insulin sensitivity at basal condition. Our recently reported case–control study in Chinese Han population showed a strong association of KCNB1 rs1051295 genotype TT with an increased risk of becoming afflicted with metabolic syndrome leading to T2D. We showed the genotype TT of this SNP was associated with several metabolic traits of metabolic syndrome, including increased waist to hip ratio (WHR), fasting insulin (FINS) levels, increased serum triglyceride (TG) levels, and decreased insulin sensitivity at basal condition [2]. In support of this possibility that Kv channels could be involved in body metabolic functions, Chandy and colleagues recently demonstrated that ShK-186, a selective and potent blocker of voltage-gated Kv1.3 channel, reduced weight gain, adiposity, and fatty liver with resultant enhancement of peripheral insulin sensitivity; and decreased serum levels of cholesterol, glucose, HbA1c, insulin, and leptin [7]
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