Association of irradiation with neoplasia in children and adolescents.

Abstract

Editorial1 March 1956ASSOCIATION OF IRRADIATION WITH NEOPLASIA IN CHILDREN AND ADOLESCENTSJOHN M. DENNIS, M.D.JOHN M. DENNIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-3-579 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Friedlander1 irradiated the enlarged thymus gland of an infant with status lymphaticus in 1907 with excellent symptomatic improvement, irradiation of enlarged thymus glands has been a common practice in this country, particularly between 1930 and 1950. Recently, reports have begun to stress the occurrence of malignancy in those children and adolescents who have had radiation for thymic enlargement and other benign conditions during infancy and early childhood.2, 3, 4, 5Radiation as a possible etiologic factor in carcinoma of the thyroid gland in children and adolescents was first suggested by Duffy and Fitzgerald2in 1950. In a series of...1 Friedlander A: Status lymphaticus and enlargement of the thymus with a report of a case successfully treated by the x-ray, Arch. Pediat. 24: 409, 1907. Google Scholar2 DuffyFitzgerald BJPJ: Thyroid cancer in childhood and adolescence. Report of twenty-eight cases, Cancer 3: 1018, 1950. CrossrefMedlineGoogle Scholar3 SimpsonHempelmannFuller CLLHLM: Neoplasia in children treated with x-rays in infancy for thymic enlargement, Radiology 64: 840, 1955. CrossrefMedlineGoogle Scholar4 Clark DE: Association of irradiation with cancer of the thyroid in children and adolescents, J. A. M. A. 159: 1007, 1955. CrossrefMedlineGoogle Scholar5 Dameshek W: The outlook for the eventual control of leukemia, New England J. Med. 250: 131, 1954. CrossrefMedlineGoogle Scholar6 WarrenAlvizouriColcock SMBP: Carcinoma of the thyroid in children and adolescents, Cancer 6: 1139, 1953. CrossrefMedlineGoogle Scholar7 ContiPatton EAGD: Study of the thymus in 7, 400 consecutive newborn infants, Am. J. Obst. and Gynec. 56: 884, 1948. CrossrefMedlineGoogle Scholar8 Doniach I: The effect of radioactive iodine alone and in combination with methylthiouracil upon tumor production in the rat's thyroid gland, Brit. J. Cancer 7: 181, 1953. CrossrefMedlineGoogle Scholar9 QuimbyWerner EHSC: Late radiation effects in roentgen therapy for hyperthyroidism. Possible bearing on the use of radioactive iodine, J. A. M. A. 140: 1046, 1949. CrossrefGoogle Scholar10 DaileyLindsayMiller MESER: Histologic lesions in thyroid gland of patients receiving radioiodine for hyperthyroidism, J. Clin. Endocrinol. 13: 1513, 1953. CrossrefGoogle Scholar11 NorrisPollock WJWF: Nodular goiters in children, Am. J. Surg. 90: 345, 1955. CrossrefMedlineGoogle Scholar12 RawsonMoney RWWL: In Recent progress in hormone research, Gregory Pincus, Editor, Academic Press 4: 397, 1949. Google Scholar13 Cooke JV: The occurrence of leukemia, Blood 9: 340, 1954. CrossrefMedlineGoogle Scholar14 Ulrich H: Incidence of leukemia in radiologist, New England J. Med. 234: 45, 1946. CrossrefMedlineGoogle Scholar15 March HC: Leukemia in radiologists in a 20 year period, Am. J. M. Sc. 220: 282, 1950. CrossrefMedlineGoogle Scholar16 KaplanBrown HSMB: Protection against radiation induced lymphoma development by shielding and partial-body irradiation of mice, Cancer Res. 12: 441, 1952. MedlineGoogle Scholar17 FolleyBorgesYamawaki JHWT: Incidence of leukemia in survivors of the atomic bomb in Hiroshima and Nagasaki, Japan, Am. J. Med. 13: 311, 1952. CrossrefMedlineGoogle Scholar18 NagaredaKaplan CSHS: The effect of hypophysectomy and x-irradiation on lymphoid organs and on the induction of lymphoid tumors in C57BL mice, J. Nat. Cancer Inst. 16: 139, 1955. MedlineGoogle Scholar19 DubilierBurnettDotterSteinberg WHWCTI: Radiation hazard during angiocardiography, Am. J. Roentgenol. 70: 441, 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTumors and HormonesDoes irradiation of infants and children cause cancer of the thyroid?Clinical Pathologic Conference* 1 March 1956Volume 44, Issue 3Page: 579-583KeywordsAdolescentsChildrenInfantsThymusThyroid Issue Published: 1 March 1956 PDF DownloadLoading ...