Abstract
Background: Irisin is a muscle-contraction-induced myokine. In previous studies, it has been related to exercise type, fitness and physical activity; however, evidence is not consistent. Thus, the aim of this study was to research the association between health-related fitness and irisin in young women.Methods: The study was designed as a prospective cross-sectional one. Young, healthy, nonsmoking women were enlisted. The sample comprised 40 overweight (OW) and 40 normal-weight (NW) individuals. The average age was 18.63 ± 0.63 and 18.78 ± 0.73 years, respectively. Components of health-related fitness, metabolic parameters, serum irisin and body composition were analyzed.Results: Statistically significant differences were found in physical tests between NW and OW groups for one-leg standing, hand grip strength, vertical jump, modified push-up, fitness index and maximal oxygen uptake (VO2MAX). There were no differences in concentrations of serum irisin between the groups. We found a positive correlation between irisin and hand grip strength (r = 0.374, p = 0.023). In a multivariate analysis adjusted by body fat, a significant association between irisin and hand grip strength was observed in OW group (β = 0.380, p = 0.026); as well, a positive association between irisin and one-leg standing test in NW group (β = 0.311, p = 0.044) was found.Conclusions: According to our findings, hand grip strength could be linked to irisin concentration in overweight young women.
Highlights
In recent years, the global prevalence of overweight and obesity has increased [1]
Skeletal muscle has been recognized as an endocrine organ, secretor of myokines, some induced by muscle contraction and proposed as intermediates between the absence of physical activity and the onset of chronic degenerative diseases related to obesity [5]
In 2012, irisin was first described as a hormone, product of cleave of a type 1 membrane protein encoded by the Fibronectin type 3 domain containing protein 5 (FNDC5), a gene capable of increasing energy expenditure, promoting weight loss and decreasing the resistance to insulin produced by diet [6] through mechanisms related to the browning of adipose and subcutaneous adipose tissue with a consequential increase in thermogenesis [7]
Summary
The global prevalence of overweight and obesity has increased [1]. The agestandardized prevalence of obesity raised from 3.2% in 1975 to 10.8% in 2014 in men and from 6.4 to 14.9% in women [2]. The association between excess weight and the development of chronic degenerative diseases is well-known [3]. Irisin Serum Concentration and Muscle Strength in order to search for preventive and therapeutic targets, focusing largely on adipose tissue and its different types [4]. Skeletal muscle has been recognized as an endocrine organ, secretor of myokines, some induced by muscle contraction and proposed as intermediates between the absence of physical activity and the onset of chronic degenerative diseases related to obesity [5]. It has been related to exercise type, fitness and physical activity; evidence is not consistent. The aim of this study was to research the association between health-related fitness and irisin in young women
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