Abstract
Purpose To evaluate the relationship between iris sectional parameters on swept-source optical coherence tomography (SS-OCT) with corneal biomechanics measured by Corneal Visualization Scheimpflug Technology (Corvis ST) in young adults with myopia. Methods 117 patients with myopia aged ≥18 years were recruited from the Eye Hospital of Wenzhou Medical University, who had complete SS-OCT and Corvis ST data. Only the left eye of each participant was selected for analysis. Iris sectional parameters included iris thickness at 750 μm from the scleral spur (IT750), iris sectional area (I-area), and iris curvature (I-curv) measured from four quadrants. Associations between the iris parameters and corneal biomechanics were analyzed using linear regression models. Results The mean age of the included young adults was 26.26 ± 6.62 years old with 44 males and 73 females. The iris parameters were different among the four quadrants. The nasal, temporal, and inferior quadrants of IT750, together with nasal and temporal quadrants of I-area, were correlated with corneal biomechanical parameters after being adjusted for age, gender, pupil diameter, and axial length. Thicker IT750 and larger I-area were related to a softer cornea. However, no association was found between I-curv and corneal biomechanics. Conclusions Iris sectional parameters measured from SS-OCT images were associated with corneal biomechanical properties in myopic eyes. Thicker IT750 and larger I-area indicate a softer cornea. IT750 and I-area may provide useful information on corneal biomechanical properties in myopic eyes.
Highlights
Myopia is one of the most common causes of preventable visual impairment and blindness, with a predicted prevalence of 50% in the world’s population in 2050.[1]
The inferior iris curvature showed a positive correlation with HC deflection length (DLL) when adjusting age and gender in model 1. In this cross-sectional study, we have provided new data on the distribution of iris structural parameters measured by swept-source optical coherence tomography (SS-OCT) including IT750, iris sectional area (I-area), and I-curv in myopic patients and their associations with corneal biomechanics measured by Corvis ST
Not all the quadrants of the iris parameters were related to corneal biomechanics, our results indicate that thicker IT750 and larger I-area in the nasal, temporal, and inferior quadrants were related to a softer cornea after being adjusted for age, gender, pupil diameter, and axial length
Summary
Myopia is one of the most common causes of preventable visual impairment and blindness, with a predicted prevalence of 50% in the world’s population in 2050.[1]. High or pathological myopia can result in irreversible ocular blinding diseases, such as choroidal neovascularization, retinal detachment, and glaucoma [2,3,4]. The corneal stiffness was reported to be reduced with the increase in the myopic degree from Corneal Visualization Scheimpflug Technology (Corvis ST, Oculus, Wetzlar, Germany) studies [10,11,12]. Accompanied by these expansions, the inner tissue especially the iris would be changed. It may be related to the development and biomechanics of the cornea and sclera, the structure of the iris and choroid, and the microcirculation of blood vessels
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