Abstract
BackgroundIL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL-33/IL1RL1 interaction has been suggested to be important in the development of atherosclerosis, genetic influences of the polymorphisms of IL33 in human ischemic stroke are unclear. The aim of this study was to examine whether the single nucleotide polymorphisms in IL33 are associated with ischemic stroke in Northern Chinese population.MethodsWe used a nested case–control study involving 90 ischemic stroke patients and 270 age-matched, sex-matched and blood pressure-matched non-ischemic stroke controls from a rural population and determined the genotypes of four polymorphisms (rs1929992, rs10975519, rs4742170, rs16924159) in IL33 by Snapshot SNP genotyping assays to assess any links with ischemic stroke.ResultsUnivariate analysis showed two single nucleotide polymorphisms (rs1929992, rs4742170) in IL33 were associated with ischemic stroke in additive, dominant, and recessive model. Binary Logistic Regression shows that rs4742170 variation is the most important factor associated with ischemic stroke (adjusted odds ratio (OR) = 1.880, 95% confidence interval (CI) = 1.316-2.686 in an additive model; OR = 2.091, CI = 1.249-3.498 in a dominant model; OR = 2.623, CI = 1.366-5.036 in a recessive model).ConclusionIn this sample of patients, genetic variation of rs4742170 in IL33 is significantly associated with the developing of ischemic stroke.
Highlights
IL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses
The risk of ischemic stroke can be influenced by genetic variation in the inflammatory agents, including Interleukin-33 (IL-33), interleukin 4 (IL-4), interleukin 6 (IL-6), intercellular adhesion molecule 1 (ICA M-1), E-selectin (E-sel), chemokine (C-C motif ) ligand 11 (CCL11), lymphotoxin (LTA) [1,5,6]
It has been reported that IL-33/ST2 pathway can protect against atherosclerosis and adipose tissue inflammation which are well-known risk factors for ischemic stroke [21]
Summary
IL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. IL-33/IL1RL1 interaction has been suggested to be important in the development of atherosclerosis, genetic influences of the polymorphisms of IL33 in human ischemic stroke are unclear. Hypercholesterolaemia and diabetes are considered as the main risk factors of ischemic stroke. The etiology and mechanisms of ischemic stroke is not clear, it is considered that genetic components play a significant role in the pathogenesis of ischemic stroke [3]. Genetic variation is an important factor causing ischemic stroke [4]. The risk of ischemic stroke can be influenced by genetic variation in the inflammatory agents, including Interleukin-33 (IL-33), interleukin 4 (IL-4), interleukin 6 (IL-6), intercellular adhesion molecule 1 (ICA M-1), E-selectin (E-sel), chemokine (C-C motif ) ligand 11 (CCL11), lymphotoxin (LTA) [1,5,6]
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