Abstract
BackgroundThe involvement of cytokines in schizophrenia (SZ) has been proposed in recent years and various studies have accumulated convergent lines of evidence. Among which, the role of interleukin-10 (IL-10) in SZ has been explored in a number of studies by investigating association of single nucleotide polymorphisms (SNPs) and susceptibility of SZ. However, the results are inconsistent since its power is limited by the individual sample size. To evaluate the overall effect between them, we conducted a meta-analysis by combining all available studies.MethodsStudies were searched from the database of PubMed, PsycINFO and ISI web of Knowledge up to Nov 2013. The meta-analysis was conducted based on statement of preferred reporting items for systematic reviews and meta-analyses (PRISMA).ResultsEleven studies including 6399 subjects (3129 cases and 3270 controls) were available for the meta-analysis. Among three investigated SNPs, rs1800872 was observed to be significantly associated with risk of SZ (AA vs. AC+CC, Pooled OR = 1.351, P-value = 2.06E-04). Meanwhile, among six haplotypes of rs1800896 - rs1800871 - rs1800872, significant associations were observed in haplotype A-C-A (Pooled OR = 1.762, P-value = 2.00E-03) and G-C-C (Pooled OR = 0.649, P-value = 2.00E-03) for Asians. These results were still significant after adjusting for multiple comparisons.ConclusionsThis meta-analysis demonstrated an SNP and two haplotypes of IL-10 significantly associated with SZ, suggesting that IL-10 might be a risk factor of SZ.
Highlights
Schizophrenia (SZ) is a complex psychiatric disorder which affects approximately 1% of the population worldwide [1]
To elucidate the pathogenic mechanism of SZ, multiple hypotheses have been proposed such as neurodevelopmental hypothesis [3], dopamine hypothesis [4], glutamate hypothesis [5] and cytokine imbalance hypothesis [6]
The cytokine imbalance hypothesis, which implies that imbalance of cytokines represents a key mechanism involved in the precipitation of schizophreniarelated pathology, is drawing growing attention of researchers, during the past two decades [7]
Summary
Schizophrenia (SZ) is a complex psychiatric disorder which affects approximately 1% of the population worldwide [1]. As key signaling molecules in inflammation, their regulatory effect extends beyond the inflammatory system, impacting on neurotransmitter metabolism, neurogenesis and the neuroendocrine system [8,9]. During these decades, researches from different areas have provided convergent lines of evidence for the involvement of cytokines in SZ. Clinical studies demonstrated that antipsychotic drugs could produce anti-inflammatory effects by altering some cytokine levels in SZ patients [13]. To evaluate the overall effect between them, we conducted a meta-analysis by combining all available studies
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