Abstract
Methods The promoter region polymorphic sites (-137C/G and -607A/C) were evaluated by polymerase chain reaction sequence specific primers (PCR-SSP) analysis using peripheral blood DNA obtained from HAC (54), HAM (44) and healthy control (150) individuals. Proviral load of infected patients (HAC and HAM) was determined by real-time PCR. Results The -607CC genotype was less frequent for HAC group (p=0.0501; OR=0.4890; CI=0.2480 to 0.9643), and infected patients (p=0.0232; OR=0.5207; CI=0.3033 to 0.8937) compared to healthy controls. The -607AC genotype was more frequent for HAC group (p=0.0387; OR=1.991; CI=1.043 to 3.801), and infected patients (p=0.0376; OR=1.757; CI=1.047 to 2.948) compared to healthy controls. No significant difference was observed for allelic and genotypic frequencies of the -137C/G among deferments groups. No significant difference was observed for allelic and genotypic frequencies of the -137C/G and -607A/C polymorphisms when correlated with proviral load. Conclusion The -607CC (high producer of IL-18) genotype exhibited protective effect against the infection, whereas the -607AC genotype conferred susceptibility to HTLV-1 infection.
Highlights
Polymorphisms in promoter region of IL-18 genes have been studied in many chronic inflammatory and infectious disorders
We evaluated the IL-18 promoter region -137C/G and -607A/C polymorphisms in HTLV-infected patients exhibiting (HAM) or not (HAC) symptomatic disease and in healthy controls
No significant difference was observed for allelic and genotypic frequencies of the -137C/G and -607A/C polymorphisms when correlated with proviral load
Summary
Polymorphisms in promoter region of IL-18 genes have been studied in many chronic inflammatory and infectious disorders. Association of interleukin - 18 gene polymorphism with susceptibility or protective effect to HTLV-1 infection Virgínia M D Wagatsuma1*, Daiani C Cilião-Alves2, Maurício C Rocha–Junior1,3, Rodrigo Haddad1,2, Oswaldo M Takayanagui2, Eduardo A Donadi2, Dimas T Covas1,2, Simone Kashima1,3
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