Abstract
BackgroudInterleukin-10(IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Polymorphisms in the IL-10 gene promoter genetically determine interindividual differences in IL-10 production. This study was performed to determined whether polymorphisms in the IL-10 gene promoter were associated with breast cancer in a Chinese Han population.MethodsWe genotyped 315 patients with breast cancer and 322 healthy control subjects for -1082A/G, -819T/C and -592A/C single nucleotide polymorphisms in the promoter region of the IL-10 gene by polymerase chain reactionerestriction fragment length polymorphism (PCR-RFLP).ResultsThere were no significant differences in genotype, allele, or haplotype frequencies in all three loci between patients and healthy controls. Analysis of breast cancer prognostic and predictive factors revealed that the -1082AA genotype was associated with a significantly increased risk of lymph node (LN) involvement (P = 0.041) and larger tumor size (P = 0.039) at the time of diagnosis. Furthermore, in the haplotype analysis of IL-10 gene, we found that patients carrying ATA haplotype were in higher LN involvement (p = 0.022) and higher tumor stage(p = 0.028) of breast cancer at the time of diagnosis compared with others.ConclusionsOur findings suggest that IL-10 promoter polymorphisms participate in the progression of breast cancer rather than in its initial development in Chinese Han women.
Highlights
Breast cancer is the most common malignancy threatening the health and life of women and it's incidence has increased in recent years in both developed and developing countries[1]
The goal of this study was to evaluate whether IL-10 gene promoter -1082A/G, -819T/C and -592A/C polymorphisms and haplotypes were associated with breast cancer in a Han Chinese population
We found strong association between tumor size and the ATA haplotypes(P = 0.028). (Table6). In this case-control study we evaluated the association between the polymorphisms of the IL-10 promoter and breast cancer in a Han Chinese population
Summary
Breast cancer is the most common malignancy threatening the health and life of women and it's incidence has increased in recent years in both developed and developing countries[1]. Biologic mechanisms leading to the development of breast cancer are not clearly understood, but the role of cytokines in cancer immunity and carcinogenesis has been well established[2]. Recent data suggest that polymorphic variations in the promoter sequences of IL-10 gene may influence the gene expression[4,5] and play a certain role in susceptibility and clinical course of breast cancer. On the one hand, increased serum IL-10 levels could facilitate development of cancer by suppressing expression of MHC class I and II antigens[7] and preventting tumor antigen presentation to CD8-cytotoxic T lymphocytes. Antiangiogenic effects of IL-10 are supposed to play a protective and preventive role against tumor
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