Association of insulin-like growth factor 2 binding protein 2 gene polymorphisms with metabolic syndrome in Han population in northwest China

Abstract

Objective To investigate the association of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) gene polymorphisms with metabolic syndrome (MS) and its related phenotypes in Han population in northwest China. Methods A case-control study was performed, which included 350 subjects with MS (MS group) and 304 subjects without MS (control group) selected with random number table from the epidemiological survey database of diabetes in Shannxi province form 2007 to 2008. Matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used as the genotyping method. rs4402960 and rs1470579 genotypes and allele frequencies between MS group and control group were analyzed. Logistic regression was used to analyze the associations of different genotypes of rs4402960 and rs1470579 with parameters of MS. Linear regression was used to analyze the relationship between IGF2BP2 gene rs4402960 and rs1470579 polymorphisms and parameters of MS. Results No single nucleotide polymorphism was found to be associated with MS. The T allele frequencies of rs4402960 in MS group and control group were 28.6% and 27.3%, respectively (χ2=0.268, P=0.605). The C allele frequencies of rs1470579 in MS group and control group were 30.1% and 29.3%, respectively(χ2=0.117, P=0.732). With the linear regression analysis adjusted for age, gender, body mass index, smoking and physical exercise, a tendency toward association between rs4402960 and systolic pressure was observed under recessive model (t=2.068, P=0.04) and additive model(t=2.144, P=0.034). Conclusions IGF2BP2 rs4402960 and rs1470579 polymorphisms are not associated with MS in Han population in northwest China. However, IGF2BP2 may be related to increased systolic blood pressure. Key words: Metabolic syndrome; Insulin-like growth factor 2 mRNA-binding protein 2 gene; Polymorphism, single nucleotide; Insulin resistance; Systolic blood pressure