Abstract
IL-10 is an anti-inflammatory cytokine with pleiotropic effect in immunoregulation and inflammation. Several recent papers reported association of the IL-10 -1082G allele with adverse outcome in sepsis [1,2]. The study objective was to investigate whether IL-10 promoter polymorphism -1082 G/A is associated with adverse outcome in severe sepsis and septic shock patients.
Highlights
There is considerable uncertainty about the reproducibility of the various instruments used to measure dyspnea, their ability to reflect changes in symptoms, whether they accurately reflect the patient’s experience and if its evolution is similar between acute heart failure syndrome patients and nonacute heart failure syndrome patients
The incidence of central venous catheter (CVC)-Resuscitation Bundles (RB) with recruitment maneuver (RM)-C was significantly lower than with standard catheters (S-C) (0 vs. 8.62 per 1,000 catheter-days, operating room (OR) = 0.13, 95% cardiac index (CI) = 0.00 to 0.86; P = 0.03)
Results of this study show that early tracheostomy, if perioperative complications
Summary
There is considerable uncertainty about the reproducibility of the various instruments used to measure dyspnea, their ability to reflect changes in symptoms, whether they accurately reflect the patient’s experience and if its evolution is similar between acute heart failure syndrome patients and nonacute heart failure syndrome patients. Conclusions Our data demonstrate that critically ill patients may be exposed to a higher FiO2 than that required to maintain adequate oxygenation These results highlight an area of ICU care that has received little study, with no published clinical trials examining the effect of FiO2 on outcome. Results Age, sex, the underlying disease and tumour stage (TNM classification), type of previous anticancer treatment, performance status, severity scores (APACHE II, Simplified Acute Physiology Score II, Sequential Organ Failure Assessment), ICU and hospital mortalities and hospital outcome at 3, 6 and 12 months were analysed. Clinical data of 277 post-transplantation patients admitted to the ICU were collected at admission and the SAPS 3 and APACHE II score calculated with respective estimated mortality rates.
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