Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population.

Zahra Heidari,Mahdieh Jafari Shahroudi,Mohsen Saravani,Mohsen Rokni,Neshat Khalafi,Mahnaz Rezaei,Azizallah Dehghan,Saeedeh Salimi,Rafael S De Molon

doi:10.1155/2021/7729238

Abstract

Background Grave's disease (GD) and Hashimoto's thyroiditis (HT) are autoimmune diseases of the thyroid gland in which genetic predisposition plays a major role in their development. Currently, the role of NLRP3 inflammasome and COX-2 has been documented in many autoimmune diseases. The purpose of the study is to delineate the impact of IL-1β (rs1143634), NLRP3 (rs3806265), and COX-2 (rs2745557) gene polymorphisms in the development of GD and HT. Methods A total of 256 newly diagnosed patients with autoimmune thyroid disease (135 patients with HT and 121 GD patients) as case groups and 145 controls were included in the study. Results Recessive and overdominant models showed a significant association between IL-1β rs1143634 SNP and HT development risk. The frequency of TT genotype and T allele of IL-1β rs1143634 SNP in the control group was significantly higher than the GD group. There was no significant association between NLRP3 rs3806265 polymorphism and HT and GD development. The frequency of GA genotype of COX-2 (rs2745557) in the control group was significantly higher than that in the HT group. There was no significant association between COX-2 rs2745557 genotypic and allelic distribution and GD development risk. The results revealed a significant relationship between some clinical features of HT and GD groups and SNPs studied. Conclusion The results manifest the significant impact of IL-1β rs1143634 and COX-2 (rs2745557) SNPs and HT development and IL-1β rs1143634 SNP on GD occurrence risk. Furthermore, a significant relationship was observed between some clinical features of HT and GD groups and studied SNPs.

Highlights

Autoimmune thyroid disease (AITD) can occur as a part of autoimmune diseases with either hyperthyroidism manifestations (GD) or hypothyroidism (HD, known as chronic lymphocytic thyroiditis) [1]
The current study concluded that as regard Hashimoto’s thyroiditis (HT), the recessive and overdominant models of IL-1β rs1143634 SNP as well as the GA genotype and dominant and overdominant models of COX-2 rs2745557 may be protective from disease development
No significant association was found between NLRP3 rs3806265 SNP and HT

Summary

Introduction

Autoimmune thyroid disease (AITD) can occur as a part of autoimmune diseases with either hyperthyroidism manifestations (GD) or hypothyroidism (HD, known as chronic lymphocytic thyroiditis) [1]. A total of 256 newly diagnosed patients with autoimmune thyroid disease (135 patients with HT and 121 GD patients) as case groups and 145 controls were included in the study. The frequency of TT genotype and T allele of IL-1β rs1143634 SNP in the control group was significantly higher than the GD group. The frequency of GA genotype of COX-2 (rs2745557) in the control group was significantly higher than that in the HT group. There was no significant association between COX-2 rs2745557 genotypic and allelic distribution and GD development risk. The results revealed a significant relationship between some clinical features of HT and GD groups and SNPs studied. The results manifest the significant impact of IL-1β rs1143634 and COX-2 (rs2745557) SNPs and HT development and IL-1β rs1143634 SNP on GD occurrence risk. A significant relationship was observed between some clinical features of HT and GD groups and studied SNPs

Objectives

Methods

Results

Conclusion