Abstract
BackgroundHepatitis C virus (HCV) infection is a significant risk factor for cirrhosis and hepatocellular carcinoma (HCC) that carry a high mortality. The study aims to investigate the effect of tumour necrosis factor (TNF)-α and interleukin (IL)-10 polymorphisms on risk and pattern of HCC in patients with HCV-related cirrhosis.ResultsThe mean age of the HCC group was 56.21 ± 4.62 years and 54.27 ± 7.63 years for the cirrhotic group. The GG genotype of TNF-ɑ and TT genotype of IL-10 showed a higher incidence of HCC in comparison to the cirrhotic group with P = 0.01 and 0.004. On the calculation of the aggressiveness index (AgI), the TT haplotype was significantly associated with more aggressive tumours in contrast to the other haplotypes with P < 0.001. There is a significant association of portal vein thrombosis, ascites and high AgI with the GG haplotype in contrast to the other haplotypes with P = 0.002, 0.029 and < 0.001, respectively, as regards TNF-α. High AgI (C) was associated with the TT haplotype of IL-10 and GG haplotype of TNF-ɑ.ConclusionOur data bring an essential association of IL-10 and TNF polymorphism with the occurrence of HCC in patients with HCV-related liver cirrhosis. The GG haplotype of TNF-ɑ and TT/AT haplotype of IL-10 are associated with the more aggressive pattern of HCC, so those patients must be treated as early as possible.
Highlights
Hepatitis C virus (HCV) infection is a significant risk factor for cirrhosis and hepatocellular carcinoma (HCC) that carry a high mortality
Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are global health problems as they are associated with high morbidity and mortality
Aim of the study In this study, we tried to assess the association of tumour necrosis factor (TNF)-ɑ and IL-10 polymorphisms with the risk and aggressiveness of HCC in patients with HCV-related cirrhosis. Patients This is a case-control study that was conducted on 73 patients attending to early detection at HCC Clinic, Specialized Medical Hospital, Mansoura University, from June 2019 to February 2020 for follow-up of HCC and 85 patients with HCV-related cirrhosis without evidence of hepatic focal lesions proved by post-contrast triphasic computed tomography (CT) scan
Summary
Hepatitis C virus (HCV) infection is a significant risk factor for cirrhosis and hepatocellular carcinoma (HCC) that carry a high mortality. The study aims to investigate the effect of tumour necrosis factor (TNF)-α and interleukin (IL)-10 polymorphisms on risk and pattern of HCC in patients with HCV-related cirrhosis. Aroucha et al concluded that polymorphisms in TNFα and interleukin (IL)-10 were associated with increased risk of HCC development in HCV chronically infected patients. The TT genotype of the IL-10 -819 was significantly correlated with advanced stages of HCC as well as with multiplicity of lesions These variants were shown to be associated with more inflammation in the liver, mediated by Th1 cytokines and may increase the risk to have HCC and bring an adverse prognosis in these patients [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
