Abstract
Methods Five groups of subjects were enrolled viz. control (n=146), HBV-carriers (n=68), chronic active HBV (n=64), HBV-cirrhotics (n=60) and HBV-related HCC (n=59). Allele-specific-PCR was performed to study various polymorphic forms of IFN-g (+874) and blood levels were estimated by ELISA. Genotype distribution was compared using chi square analysis and the odds ratios (ORs) and 95% CI were calculated to express the relative risk.
Highlights
Hepatitis B Virus (HBV) infection is a primary causative factor for hepatocellular carcinoma (HCC), the fifth most frequent cancer, worldwide
The present study evaluated the association of IFN-g +874T>A polymorphism and its levels with HBV related HCC risk in Indian population
Allele-specific-PCR was performed to study various polymorphic forms of IFN-g (+874) and blood levels were estimated by ELISA
Summary
Hepatitis B Virus (HBV) infection is a primary causative factor for hepatocellular carcinoma (HCC), the fifth most frequent cancer, worldwide. The present study evaluated the association of IFN-g +874T>A polymorphism and its levels with HBV related HCC risk in Indian population
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