Abstract
BackgroundTuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility.MethodsWe performed a hospital‐based case–control study to assess the genetic influence of single‐nucleotide polymorphisms (SNPs) in the HLA (HLA‐DPA, HLA‐DPB, and HLA‐DQB) on the development of TB. There were 248 TB‐infected cases and 340 healthy controls in this study.ResultsThe HLA‐DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039–2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA‐DQB2 rs7453920 G>A.ConclusionThese results suggested that the functional HLA‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well‐designed studies are expected to confirm these preliminary findings.
Highlights
Tuberculosis (TB), an infectious disease caused by mycobacterium TB (MTB) infection, is the second‐leading cause of death worldwide according to World Health Organization (WHO) Global TB report (2016)
Despite the proven role of human leukocyte antigens (HLA)‐DP rs3077, HLA‐DP rs9277535, and HLA‐DQ rs7453920 polymorphisms in the devolvement of diseases like hepatitis B, no current evidence shows whether HLA‐ DPA1 (OMIM: 142880), HLA‐DPB1 (OMIM: 142858), and HLA‐DQB2 (OMIM: 615161) genetic variants could influence the outcome of TB
In the recessive model, when the HLA‐DQB2 rs7453920 GG/GA genotype was applied as the reference group, the association between the AA genotype and the risk of TB was less than tobacco
Summary
Tuberculosis (TB), an infectious disease caused by mycobacterium TB (MTB) infection, is the second‐leading cause of death worldwide according to World Health Organization (WHO) Global TB report (2016). The southern part of Xinjiang Uygur Autonomous Region in the Northwest China is the home to the Uygur people (a Turkic ethnic group) where they live in isolation from the Han people (an east Asian ethnic group and nation) Despite the proven role of HLA‐DP rs3077, HLA‐DP rs9277535, and HLA‐DQ rs7453920 polymorphisms in the devolvement of diseases like hepatitis B, no current evidence shows whether HLA‐ DPA1 (OMIM: 142880), HLA‐DPB1 (OMIM: 142858), and HLA‐DQB2 (OMIM: 615161) genetic variants could influence the outcome of TB. In light of the biological and pathologic effect of HLA‐DPA, HLA‐DPB, and HLA‐DQ in disease immunity, we hypothesize that these variant genes play an important role in the development and susceptibility to TB. We enrolled 248 PTB cases and 340 controls to analyze three SNPs in a Xinjiang Uygur population that may be associated with TB development
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