Association of Human Leukocyte Antigens Class II Variants with Susceptibility to Hidradenitis Suppurativa in a Caucasian Spanish Population.

J Gonzalo Ocejo-Vinyals,Ricardo Blanco,Juan Cantos-Mansilla,Miguel A Gonzalez-Gay,Iosune Vilanova,Marcelo A Fernández-Viña,Marcos A González-López

doi:10.3390/jcm9103095

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease of the hair follicle typically presenting recurrent, painful, and inflamed lesions on the inverse areas of the body. Although its pathogenesis remains unknown, the immune system appears to play a potential role. To date, two previous studies have not found any association between the Human Leukocyte Antigen system (HLA) and HS. In this study we analyzed the HLA-A, -B, -C; and DRB1, -DQA1, and –DQB1 allele distribution in 106 HS patients and 262 healthy controls from a Caucasian population in Cantabria (northern Spain). HLA-A*29 and B*50 were significantly more common in HS patients and A*30 and B*37 in controls, but these associations disappeared after statistical correction. DRB1*07, DQA1*02, and DQB1*02 were significantly more common in controls (p 0.026, p 0.0012, and p 0.0005, respectively) and the HLA allele DQB1*03:01 was significantly more common in HS patients (p 0.00007) after the Bonferroni correction. The DRB1*07~DQA1*02~DQB1*02 haplotype was significantly more common in controls (p < 0.0005). This is the first study showing an association between HLA-class II and HS. Our results suggest that HLA-II alleles (DRB1*07, DQA1*02, DQB1*02, and DQB1*03:01) and the DRB1*07~DQA1*02~DQB1*02 haplotype could influence resistance or susceptibility to HS.

Highlights

Hidradenitis suppurativa (HS), or acne inversa, is a debilitating and recurrent chronic inflammatory cutaneous disease that usually presents after puberty with painful, inflamed lesions on the apocrine gland-bearing areas of the body, most commonly the axillae, inguinal, and anogenital regions [1].HS affects mostly young adults and the female-to-male ratio is approximately 3:1 [2]
Lapins et al [24] analyzed the frequencies of Human Leukocyte Antigen system (HLA)-A, -B, and HLA-DR alleles in 42 unrelated Swedish patients with HS and 250 healthy controls. These results found no association between any HLA alleles and genetic susceptibility to HS
All allele and haplotype frequencies were in Hardy–Weinberg equilibrium (HWE)

Summary

Introduction

Hidradenitis suppurativa (HS), or acne inversa, is a debilitating and recurrent chronic inflammatory cutaneous disease that usually presents after puberty with painful, inflamed lesions on the apocrine gland-bearing areas of the body, most commonly the axillae, inguinal, and anogenital regions [1].HS affects mostly young adults and the female-to-male ratio is approximately 3:1 [2]. Several factors such as cigarette smoking, obesity, diabetes mellitus, ethnicity, stress, and drugs have been related to an increased predisposition to HS [2,3,4,5,6,7,8,9].

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