Year-end Sale % OFF 
Abstract
Different forms of virus induced infections are related to the enlarged risk of diabetogenic diseases in humans. Human cytomegalovirus infection has been advised by multiple studies to be one amongst the causative agents. HCMV infection has been linked to the development of both type 1 and type 2 diabetes as well as post-transplantation diabetes. The limited amount of available data indicates that active HCMV infection increases the risk of diabetes by either inhibiting the release of insulin from pancreatic cells or specifically destructing the pancreatic β cells. The mechanism is mainly attributed to the expression of pro-inflammatory cytokines that eventually results in programmed cell death or critical disturbances to the functioning of the β-cells.
Highlights
The incidence of diabetes is rising at a considerable rate throughout the world, and this may be due to many factors that can directly or indirectly participate in the etiology of the disease
Previous studies reported a significant association between high titre of anti-cytomegalovirus and anti-islet cell antibodies and showed that asymptomatic cytomegalovirus infection is associated with increased risk of new-onset type I diabetes and impaired insulin release after renal transplantation [2,3]
The findings indicated an up to 12 fold greater odds of having type 2 diabetes for persons previously exposed to HCMV [4]
Summary
The incidence of diabetes is rising at a considerable rate throughout the world, and this may be due to many factors that can directly or indirectly participate in the etiology of the disease. Previous studies reported a significant association between high titre of anti-cytomegalovirus and anti-islet cell antibodies and showed that asymptomatic cytomegalovirus infection is associated with increased risk of new-onset type I diabetes and impaired insulin release after renal transplantation [2,3]. Another independent study revealed that the HCMV seropositivity is significantly associated with various indicators of glucose regulation and HCMV infection might be a risk factor for the development of type 2 diabetes in the elderly [4]. This review very briefly highlights the association between HCMV infection and the development of diabetes, alongside focusing on the immunological attributes behind this association
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
