Abstract
Background. The correlation between H-type hypertension and acute ischemic stroke remains uncertain. Objective. The present study was designed to explore the possible relationship between H-type hypertension and severity and prognosis of acute ischemic stroke. Method. We included 372 patients with acute ischemic stroke and divided them into four groups: H-type hypertension group, simple hypertension group, simple hyperhomocysteinemia (HHcy) group, and the control group. NIHSS score was measured at both admission and two weeks later. mRS score, stroke recurrence, cardiovascular event, or all-cause mortality was recorded at 3-month and 1-year follow-up. Result. The results showed that the NIHSS score on admission in the H-type hypertension group (6.32 ± 5.91) was significantly higher than that in the control group (3.97 ± 3.59) (P < 0.05), while there was no obvious association between H-type hypertension and NIHSS score after 2-week treatment (P = 0.106). Endpoint events incidence in H-type hypertension group was the highest; however, in the cox regression model of multiple factor analysis, H-type hypertension was not an independent risk factor. Conclusion. H-type hypertension may result in early functional deterioration and higher incidence rate of endpoint events but not act as an independent risk factor.
Highlights
Ischemic stroke has become the leading cause of disability and mortality in China [1]
The present study was conducted in Stroke Center of First Hospital Affiliated to Soochow University and included 372 patients who had been diagnosed with acute ischemic stroke according to the World Health Organization (WHO) criteria [10] and confirmed
The most common stroke subtype observed in our study was large artery atherosclerosis (LAA) (53%), in turn followed by small artery occlusion (SAO), cardioembolism (CE), stroke of other determined etiology (SOE), and stroke of undetermined etiology (SUE)
Summary
Ischemic stroke has become the leading cause of disability and mortality in China [1]. Previous studies suggested that H-type hypertension could be positively related to the risk of cardio-cerebrovascular [8, 9] Whether it could be regarded as an independent predictor of severity and prognosis of ischemic stroke has not been fully clarified. This study was designed to explore the possible relationship between H-type hypertension and acute ischemic stroke. The present study was designed to explore the possible relationship between H-type hypertension and severity and prognosis of acute ischemic stroke. We included 372 patients with acute ischemic stroke and divided them into four groups: H-type hypertension group, simple hypertension group, simple hyperhomocysteinemia (HHcy) group, and the control group. H-type hypertension may result in early functional deterioration and higher incidence rate of endpoint events but not act as an independent risk factor
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