Association of HTR2A and HTR2C gene polymorphisms and the efficacy of rehabilitation measures in narcology patients

Abstract

In recent years, there has been an increase in the number of patients with combined addiction to several psychoactive substances, as well as with addiction to psychostimulants. Meanwhile, there are no methods of rehabilitation of these patients based on clinical characteristics and the state of patients’ genetic biomarkers within the personalized approach. It seems relevant to study the influence of some pathogenetic biomarkers on the efficacy of rehabilitation measures in patients with combined addiction to several psychoactive substances and psychostimulant addiction in order to improve the quality of medical care for these patients. The aim of the study was to determine the association of HTR2A and HTR2C gene polymorphisms and the effectiveness of rehabilitation measures in patients with combined addiction to several psychoactive substances and psychostimulant addiction. Materials and methods. The study included 325 patients with combined addiction to several psychoactive substances and psychostimulant addiction. Methods: clinical and psychopathological, anamnestic, catamnestic, molecular genetics, and statistical methods. The effectiveness of rehabilitation work was assessed by the number of patients who chose treatment in the conditions of inpatient or outpatient rehabilitation due to primary motivational work with them and by the duration of remission as a result of the program. The results of the study. The patients were divided into 3 groups: patients with only psychostimulant addiction, patients with combined addiction to several psychoactive substances, and those with psychostimulant addiction and comorbid psychiatric pathology. The association of polymorphism of genes controlling the work of the serotonin system of the brain (HTR2A and HTR2C) and the efficacy of motivational work aimed at undergoing a rehabilitation program and the duration of remissions was revealed. Conclusion. Based on the analysis of the obtained results, the association of some clinical characteristics and HTR2A and HTR2C gene polymorphisms with the effectiveness of rehabilitation measures in patients with combined addiction to several psychoactive substances, psychostimulant addiction, and with comorbid psychiatric pathology was established.