Abstract
The study investigated the possible association between HLA allele frequency and the preference and intake of dairy milk. Ninety-nine Japanese subjects (72 male, 27 female), aged 18–29 years (mean 20.4 years), provided their preference and intake of cow’s milk, by answering ‘like’ or ‘dislike’, and ‘often or daily’ or ‘seldom or never’. Their HLA class II genes (DRB1, DQA1 and DQB1) were analyzed by the polymerase chain reaction sequence specific oligonucleotide probes method. Among the 99 subjects, 37 answered ‘like’ and 62 answered ‘dislike’. For milk intake frequency, 56 of subjects answered ‘often or daily’ and 43 answered ‘seldom or never’. The frequency of HLA-DQA1∗0102 was significantly increased in the ‘dislike’ group for milk preference. The results of the present study suggest that the preference for cow’s milk is negatively associated with the frequency of HLA-DQA1∗0102.
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