Abstract
Veterinaria México OA ISSN: 2448-6760Cite this as:Salas Araujo YJ, Aburto E, Alonso R, Márquez Alvarado AA, Corona Monjaras H, Romero Romero L. Association of histological features with potential risk factors and survival in canine mammary tumors. Veterinaria México OA. 2016;3(1). doi: 10.21753/vmoa.3.1.359The epidemiological and clinicopathological features of canine mammary tumors may provide valuable information to facilitate analysis of the behavior of the disease and represent a potential tool for the study of breast cancer in women. The aim of this study was to associate the histological features of canine mammary tumors with potential risk factors and survival. One hundred and seventy-eight mammary tumors were collected from 80 female dogs. The statistical analyses consisted of a series of univariate studies and frequencies of the different study variables, such as a bivariate analysis with the Chi squared test (χ2), a relative risk and Kaplan Meier survival analysis, and a multiple correspondence analysis was used to correlate the tumor’s biological behavior with the dogs’ breed. Most patients were older than 8 years and had at least one malignant tumor, which was usually solitary and measured more than 6 cm; these patients had poor survival. The most frequent tumors were a complex adenoma, benign mixed tumor, carcinoma complex and mixed type carcinoma. The most commonly affected breeds were Poodle, Cocker Spaniel and Dachshund, and the breeds at the highest risk of tumor development were Cocker Spaniel, Labrador Retriever and German Shepherd. Overall, the data indicated that mammary tumors in dogs mainly affected older females with malignant tumors and that there were high mortality and short-term survival rates. However, the most commonly affected breeds were not necessarily the most susceptible. Our data do not support the hypothesis of an increased risk of canine mammary tumors in nulliparous female dogs.Figure 1. Frequency of canine mammary tumors according to their size (cm).
Highlights
Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Av
El análisis estadístico consistió en análisis de frecuencia de las variables de estudio, análisis bivariado con Chi cuadrado (χ2), riesgo relativo, análisis de supervivencia Kaplan-Meier y un análisis de correspondencia múltiple que se utilizó para correlacionar el comportamiento biológico del tumor con la raza de las perras
26) Sorenmo KU, Shofer FS, Goldschmidt MH
Summary
Las características epidemiológicas y clínico-patológicas del tumor mamario canino es información valiosa para analizar el comportamiento de la enfermedad y son un recurso potencial para promover avances en el cáncer de mama en mujeres. En un estudio retrospectivo que incluye biopsias de perras que mostraron lesiones de glándulas mamarias, Salas et al (2015) observaron las características epidemiológicas de los tumores mamarios caninos y concluyeron con lo siguiente: 1) alta incidencia (16.8%) de tumores mamarios en perras enteras, 2) frecuencias similares en tumores benignos (47.7%) y malignos (47.5%), 3) los tumores epiteliales fueron los más comunes, 4) las más afectadas fueron hembras adultas seniles (9 a 12 años), de raza pura y de tamaño pequeño (Poodle y Cocker Spaniel), y 5) la cantidad de tumores malignos se incrementó en los últimos cuatro años del estudio. El incremento en los casos de enfermedad neoplásica en medicina veterinaria, entre ellas las neoplasias mamarias, demanda un mayor desarrollo de la oncología veterinaria; en tal sentido, estudios que correlacionan características histológicas con resultados clínicos, así como aquellos que definen los factores de riesgo más importantes, asociados con el desarrollo y comportamiento de los tmc, son de gran utilidad para entender la enfermedad. La hipótesis planteada presume que existe asociación entre las características histológicas, los factores de riesgo y la supervivencia, en las perras con tumores mamarios evaluados
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