Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components.

Santosh Kumar Sah,Binod Kumar Lal Das,Sunil Pandey,Nirmal Baral,Madhab Lamsal,Saroj Khatiwada,Rajendra Kc

doi:10.1186/s40064-016-1933-y

Santosh Kumar Sah, Binod Kumar Lal Das + Show 5 more

Open Access

https://doi.org/10.1186/s40064-016-1933-y

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Journal: SpringerPlus	Publication Date: Mar 3, 2016
Citations: 15	License type: CC BY 4.0

Affiliation: B.P. Koirala Institute of Health Sciences

Abstract

Metabolic syndrome (MetS) has been found to be associated with inflammatory molecules. This study was conducted among 125 MetS patients at B P Koirala Institute of Health Sciences, Dharan, Nepal to find an association of high-sensitivity C-reactive protein (hs-CRP) and serum uric acid with MetS components. Anthropometric measurements, blood pressure, medical history and blood samples were taken. Estimation of hs-CRP, serum uric acid, blood glucose, triglyceride and high density lipoprotein (HDL) cholesterol was done. hs-CRP had positive correlation with blood glucose (r = 0.2, p = 0.026) and negative with HDL cholesterol (r = −0.361, p < 0.001). Serum uric acid had positive correlation with waist circumference (r = 0.178, p = 0.047). Patients with elevated hs-CRP and uric acid had higher waist circumference (p = 0.03), diastolic BP (p = 0.002) and lower HDL cholesterol (p = 0.004) than others. Elevated hs-CRP and high uric acid were individually associated with higher odds for low HDL cholesterol (7.992; 1.785–35.774, p = 0.002) and hyperglycemia (2.471; 1.111–5.495, p = 0.029) respectively. Combined rise of hs-CRP and uric acid was associated with severity of MetS (p < 0.001) and higher odds for hyperglycemia (8.036; 2.178–29.647, p = 0.001) as compared to individual rise of hs-CRP or uric acid. The present study demonstrates that hs-CRP and serum uric acid are associated with MetS components, and the combined rise of hs-CRP and uric acid is associated with the increase in severity of MetS.

Highlights

Metabolic syndrome (MetS) is the clustering of several cardiovascular risk factors leading to increased risk of developing cardiovascular disease (CVD) and dying (Paoletti et al 2006)
Only significant difference (p = 0.009) in MetS component; waist circumference was observed among patients with normal uric acid and hyperuricemic patients
Our findings show that serum uric acid level increases with increase in severity of MetS, and prevalence of hypertension, hyperglycemia and low high density lipoprotein (HDL) cholesterol increases with the rise in serum uric acid

Summary

Introduction

Metabolic syndrome (MetS) is the clustering of several cardiovascular risk factors leading to increased risk of developing cardiovascular disease (CVD) and dying (Paoletti et al 2006). It is important to study the factors responsible for rapid rise of MetS and investigate markers that can predict risk for MetS early and the risk for future adverse events. Hs-CRP is highly predictive of subsequent risk of cardiovascular events and diabetes mellitus in apparently healthy men and women (den Engelsen et al 2012). Hs-CRP may serve as early marker for CVD and MetS, there is less evidence about relationship between hs-CRP level and the severity of MetS (as quantified by the increasing concurrence of individual MetS components; 3, 4 or 5), and there are evidences that

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