ASSOCIATION OF HELICOBACTER PYLORI WITH PEPTIC PERFORATION

Abstract

Background: Helicobacter pylori infections have been proved to be associated with peptic ulcer disease, gastritis, gastric adenocarcinoma, gastric lymphoma. The role of Helicobacter pylori is not well established in cases of peptic perforation. The objective of this study is to observe the presence or absence of Helicobacter pylori in cases of perforated peptic ulcer. Methods: We have done a cross sectional observational study with data from patients presenting to the emergency of a tertiary care hospital with perforated peptic ulcer and undergoing emergency exploratory laparotomy followed by omental patch repair. We collected mucosal biopsy samples from gastric/duodenal mucosa along margin of perforation site of these patients and performed rapid urease test using Rapid Urease Test kit. Of the 50 participants in our study, 48 (96%) were males Results: and 2 (4%) were females. 37 (74%) cases had perforation at pre pyloric region, and in 13 (26%) cases perforation was present at rst part of duodenum. Rapid urease test by Rapid Urease Test kit was found to be positive in 6 (12%) cases and negative among 44 (88%) cases. Conclusion: In our study, frequency of Helicobacter pylori in perforated peptic ulcer cases was found to be only 12% which proves that there may be other contributing factors in perforated peptic ulcer cases, which need further evaluation. Objective: To assess the presence of Helicobacter pylori in mucosal surface of stomach and duodenum in patients undergoing emergency exploratory laparotomy followed by omental patch repair in patients of peptic perforation.