Association of Helicobacter pylori and Left Ventricular Ejection Fraction in Patients with Acute Myocardial Infarction

Abstract

Background: Helicobacter pylori (H. pylori) causes continuous inflammation of the stomach. It is suspected that H. pylori infection is associated with an inflammatory response in acute myocardial infarction (AMI). This research was aimed at analyzing the association of Helicobacter pylori infection and the degree of reduction in left ventricular ejection fraction (LVEF) in patients with AMI, the number of coronary heart disease (CHD) risk factors with H. pylori on AMI incident, and association of type of AMI and H. pylori on AMI incident. Method: This is a prospective cohort study with observational-analytic method in AMI patients at ICCU of Prof. Dr. R. D. Kandou General Hospital Manado in 2015-2016. Data retrieval was done by filling out questionnaires, examination of blood samples, serology test to examine the presence of H. pylori, and echocardiography examination in patients with AMI. Results: Statistical analysis showed no significant association between H. pylori with the degree of reduction in LVEF in AMI patients (p=0.713), and the number of CHD risk factors (p=0.087). There was a significant association between H. pylori and types of IMA (p=0.017). There were more ST-Elevation Myocardial Infarction (STEMI) patients infected with H. pylori. Conclusion: There is no significant association between H. pylori infection and the degree of reduction in LVEF in AMI patients, and also the number of CHD risk factors. However, there is a significant association between AMI type and H. pylori on AMI, to wit there are more STEMI patients with H. pylori infections.