Abstract
This prospective study investigates the relationship between Hashimoto's thyroiditis (HT) and thyroid cancer (TC) in patients with thyroid nodules (TNs). We prospectively examined 2100 patients with 2753 TNs between January 5, 2010 and August 15, 2013. A total of 2023 patients with 2669 TNs met the inclusion criteria of TN ≥5 mm and age ≥18 years. Each patient had blood drawn before fine-needle aspiration biopsy (FNAB) for the following measurements: TSH, free thyroxine, free tri-iodothyronine, thyroid peroxidase antibody (TPOAb), and antithyroglobulin antibody (TgAb). Diagnosis of TC was based on pathology analysis of thyroidectomy tissue. The associations of TC with the independent variables were determined by univariate and multivariate logistic regression analysis and reported as adjusted odds ratio (OR) with 95% CI. A total of 248 malignant nodules were found in 233 patients. There was an association of TC with both increased serum TgAb concentration and age<45 years. An elevated serum TgAb concentration was found in 10.2% of patients (182 of 1790) with benign nodules as compared with 20.6% of patients (48 of 233) with malignant nodules (P≤0.0001). TgAb (OR=2.24: CI=1.57, 3.19) and TSH ≥1 μIU/ml (OR (95% CI)) OR: 1.49 (1.09, 2.03) were significant predictors of TC in multivariate analysis controlling for age and gender. TC was not associated with serum concentrations of TPOAb. In patients with TN, elevated serum concentration of TgAb and TSH ≥1 μIU/ml are independent predictors for TC. The association between HT and TC is antibody specific.
Highlights
Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease and the most common cause of hypothyroidism (Jankovic et al 2013)
Epidemiological and histological data indicate that thyroid cancer (TC) frequently occurs in the context of one of the most common autoimmune thyroid diseases, HT, and that TC is frequently infiltrated by inflammatory-immune cells (Guarino et al 2010)
HT is characterized by infiltration of the thyroid gland by inflammatory cells
Summary
Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease and the most common cause of hypothyroidism (Jankovic et al 2013). HT is characterized by infiltration of the thyroid gland by inflammatory cells. This often leads to hypothyroidism due to destruction and eventual fibrous replacement of the parenchymal tissue. The relationship between HT and papillary carcinoma (PC) was first proposed by Dailey et al (1955). Since this initial description, the association between the diseases has been repeatedly reported and highly debated in the literature and remains controversial (Cunha et al 2011)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
