Abstract
Abstract Biliary atresia (BA) is the most important cause of liver cirrhosis in children. Even with an early Kasai procedure, some patients fail to establish bile drainage. The roles of the gut microbiota and host genetic variation remain unclear. We studied the sequential fecal microbiome postoperatively and performed genome-wide scanning of copy number variation in two BA infants with different outcomes. Our results showed decreased gut microbiota diversity and genetic loss at 7q36.3 in the patient with persistent jaundice. Bifidobacterium breve was increased 1 month after a successful operation in the other patient. Our findings suggest that interactions between host genome variation and the gut microbiota are novel biomarkers for disease progression or resolution in BA.
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