Association of green tea consumption with mortality due to all causes and major causes of death in a Japanese population: the Japan Public Health Center-based Prospective Study (JPHC Study)

Eiko Saito,Motoki Iwasaki,Y Furusugi,Mitsuhiko Noda,I Asano,Taichi Shimazu,H Takaesu,Shoichiro Tsugane,Y Roppongi,N Onga,Y Tanaba,Shizuka Sasazuki,T Minamizono,E Maruyama,Hiroyasu Iso,Norie Sawada,S Yamato,M Irei,H Sakiyama,K Kobayashi,Taiki Yamaji,Manami Inoue,M Urata,Mariko Uehara ,Minoru Noda ,Junko Ishihara ,Koichi Minato ,Akira Okayama ,Manabu Tsukada ,Tomoki Ikuta ,Joice Fabiola Meneguel Ogata ,Yoshiomi Hatayama ,Yutaka Takashima ,Shin‐Ya Nagasawa ,Keiko Miyakawa ,Fumio Kobayashi ,Fumitake Saito ,Suminori Kono ,Toshifumi Mannami ,Naoyuki Tsuchiya ,Michinori Kabuto ,Sayumi Watanabe ,Takeshi Fujieda ,Minori Kinjo ,H Sueta ,Ribeka Takachi ,Ritsuko Saito ,E Takara ,Tetsuya Mizoue ,Kazuo Motegi ,Satoshi Sasaki ,Toshiyuki Nakasone ,Toru Seo ,Fuyuaki Ide ,Shosui Matsushima ,Yoshinori Ito ,Yukie Yoshida ,Yoshimi Kishimoto ,Yoshitaka Tsubono ,Yoshimichi Miyajima ,F Horii ,Tomoyuki Hanaoka ,Hidehiko Sato ,Naoyuki Okamoto ,Miwa Yamaguchi ,Kenji Matsui ,Shoji Fukushima ,Shoko Komatsu ,Akio Koizumi ,Satoshi Maruyama ,Yosuke Matsumura ,Takaaki Kondo ,Yoritoshi Kobayashi ,Akira Terao ,Nobuyuki Hamajima ,Yasuyoshi Watanabe ,Nobufumi Yasuda ,Masataka Suzuki ,Naoya Suzuki ,H Uchino ,Hiroyuki Shimizu ,Shusuke Natsukawa ,Takashi Tagami ,Yujiro Sano ,Yasushi Honda ,Suketami Tominaga ,Akiko Ioka ,Wakiko Ajiki ,Kenichi Nakamura ,Koji Imoto ,Toshi Abe ,Sei Sato ,Naoko Nagai ,Hironori Yamaguchi ,Abdulaziz Seiko ,Hironobu Sanada ,Tomotaka Sobue ,Katsutoshi Okada ,Mitsuru Ichii ,Masakazu Iida ,Kunihiro Suzuki ,Mikio Doi ,Tamaki Fukuyama ,Hiroki Goto ,Kazumasa Yamagishi ,Atsuhiko Murata ,Yoshihiro Kokubo ,Fumi Ito ,Susumu Sakurai ,Yoshio Kawaguchi ,Misao Takano ,Munehito Machida ,Yoshinori Ishikawa ,Isao Saito ,Mikio Katagiri ,Hiroyuki Sugimura ,Isamu Hashimoto ,Kunio Aoki ,Michiyo Yamakawa ,Yoshiro Shirai ,Hiroyuki Doi ,Masayuki Akabane ,Tomoyuki Takashima ,Ryohei Sasaki ,Shinichi Baba ,Yusuke Miyagawa ,Hisatoyo Yazawa ,Masamitsu Konishi ,Tomoko Kadowaki ,Suminori Akiba

doi:10.1016/j.annepidem.2015.03.007

Abstract

PurposeWe examined the association between green tea consumption and mortality due to all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries, and other causes of death in a large-scale population-based cohort study in Japan. MethodsWe studied 90,914 Japanese (aged between 40 and 69 years) recruited between 1990 and 1994. After 18.7 years of follow-up, 12,874 deaths were reported. The association between green tea consumption and risk of all causes and major causes of mortality was assessed using the Cox proportional hazards regression model with adjustment for potential confounders. ResultsHazard ratios for all-cause mortality among men who consumed green tea compared with those who drank less than 1 cup/day were 0.96 (0.89–1.03) for 1–2 cups/day, 0.88 (0.82–0.95) for 3–4 cups/day, and 0.87 (0.81–0.94) for more than 5 cups/day (P for trend <.001). Corresponding hazard ratios for women were 0.90 (0.81–1.00), 0.87 (0.79–0.96), and 0.83 (0.75–0.91; P for trend <.001). Green tea was inversely associated with mortality from heart disease in both men and women and mortality from cerebrovascular disease and respiratory disease in men. No association was found between green tea and total cancer mortality. ConclusionsThis prospective study suggests that the consumption of green tea may reduce the risk of all-cause mortality and the three leading causes of death in Japan.

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