Abstract
This study is an effort to evaluate the association between glycated-albumin and various biochemical parameters in Saudi type-2 diabetic patients. Ninety long-standing (>10 years) type-2 diabetic subjects (51 males, 39 females) serum was analyzed for glycated albumin, fasting blood glucose, hemoglobin1c, cholesterol, triglyceride, albumin, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, aspartate transaminase, alkaline phosphatase, alanine transaminase and total bilirubin. Correlation, principal components analysis, covariance and statistical differences were conducted using SPSS for both male and female participants. The average age (years) of female and male participants was 51.0±10.2 and 51.6±14.1, respectively. Hemoglobin1C was significantly associated with fasting blood glucose (r=0.637,P<0.01). No significant differences between men and women were observed in the glycemic markers, lipid profile and liver function tests. Both men and women showed no significant differences in glycated-albumin irrespective of age and hemoglobin1c covariance. The regression model revealed that low-density lipoprotein, aspartate transaminase and alanine transaminase are significantly associated with glycated-albumin. Men’s glycated-albumin was observed to be significantly associated with hemoglobin1c only, while women’s glycated-albumin is highly associated with low-density lipoprotein only. Glycated-albumin was also co-varied with low-density lipoprotein. Glycated-albumin could be employed for screening high risk diabetic patients for early diagnosis of dyslipidemia and appropriate intervention with lipid-decreasing drugs. Current findings provide novel insights on the use glycated-albumin as clinical chemistry maker.
Highlights
Diabetes mellitus (DM) is a state of chronic hyperglycemia due to complete or comparative insulin deficiency (Inzucchi et al, 2012)
Ninety long-standing (>10 years) type-2 diabetic subjects (51 males, 39 females) serum was analyzed for glycated albumin, fasting blood glucose, hemoglobin1c, cholesterol, triglyceride, albumin, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, aspartate transaminase, alkaline phosphatase, alanine transaminase and total bilirubin
The regression model revealed that low-density lipoprotein, aspartate transaminase and alanine transaminase are significantly associated with glycated-albumin
Summary
Diabetes mellitus (DM) is a state of chronic hyperglycemia due to complete or comparative insulin deficiency (Inzucchi et al, 2012). The glycated hemoglobin level is affected by the mean glucose levels and RBCs life span so that if RBCs life span reduced, the hemoglobin will have fewer time to turn into glycated form. In this case the glycated hemoglobin test will be less sensitive (Khera et al, 2015). The augmented glucose levels present in DM produces amplified glycation of all proteins, including, albumin (Barlovic et al, 2011). Quantification of the total glycation reaction consequential from the binding of glucose with free amino groups in proteins available in the blood is utilized to screen the level of blood glucose that has normally been present in body fluids over a previous period. The current study was designed to assess the association between glycated albumin for the assessment control in Saudi patients with long standing T2DM
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