Association of glucocorticoid receptor gene polymorphism and occupational stress with hypertension in desert petroleum workers in Xinjiang, China

Ning Tao,Wenfeng Wu,Xinjuan Xu,Hengqing An,Jiwen Liu,Hua Ge

doi:10.1186/s12881-018-0688-4

Abstract

BackgroundThe aim of this study was to investigate the occupational stress and hypertension in desert petroleum workers in Xinjiang, and to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension.MethodsUsing cluster sampling, 1280 desert petroleum workers of 3 petroleum fields in Xinjiang Karamay were randomly selected as the target group for this study. According to the inclusion criteria, a total of 1080 workers were included as the baseline for this study. We followed these workers for 2 years to investigate their occupational stress and hypertension. The polymorphism of GR gene was detected by polymerase chain reaction-restriction fragment length polymorphism. We applied appropriate statistical methods to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension.ResultsAfter 2 years of follow-up, there were 995 desert petroleum workers in the queue. The study showed that the incidence of hypertension in desert petroleum workers were 19.4%. Compared with the baseline data, the level of occupational stress increased, and with the increase of occupational stress, the incidence of hypertension was gradually increasing. A positive relationship was observed in the GR BCL1 gene polymorphisms and hypertension. Relative to the CC genotype, carries of the GG genotype had a significantly higher risk of hypertension (OR = 2.830). With the combination of genotype CG and GG, carries of CG and GG increased the risk of hypertension (adjusted OR = 2.238, 95%CI:1.104–4.940). There was no significant association between GR G678S gene polymorphisms and hypertension.ConclusionGR gene polymorphism and occupational stress of desert petroleum workers were important risk factors for hypertension.

Highlights

The aim of this study was to investigate the occupational stress and hypertension in desert petroleum workers in Xinjiang, and to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension
Researchers conducted a five-year follow-up survey of 1394 white-collar workers, and the results revealed that men who had been exposed to high-intensity jobs for a long time were more likely to suffer from high blood pressure and that women had long-term work under high pay-low return conditions would lead to increased systolic blood pressure [16]
In this study, 1280 desert petroleum workers were randomly selected by cluster sampling

Summary

Introduction

The aim of this study was to investigate the occupational stress and hypertension in desert petroleum workers in Xinjiang, and to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension. Hypertension is a most common chronic disease that threatens human health caused by the interaction of environmental, social and genetic factors, and is the most important risk factor for cardiovascular and cerebrovascular disease [10]. A cross-sectional survey of 1035 managers demonstrated that high pay-low return work patterns would increase the occupational stress of workers and significantly Related to hypertension [14]. Studies have shown that chronic stress can cause blood pressure fluctuations and as a potential risk factor for hypertension [15]. While dealing with the sudden occupational injuries caused by occupational stress, desert petroleum workers should pay attention to adverse social psychological pressure on the physical and mental health

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Discussion

Conclusion