Abstract
BackgroundGestational diabetes mellitus (GDM), a common endocrine disorder with rising prevalence in pregnancy, has been reported to be associated with alteration of gut microbiota in recent years. However, the role of gut microbiome in GDM physiopathology remains unclear. This pilot study aims to characterize the alteration of gut microbiota in GDM on species-level resolution and evaluate the relationship with occurrence of GDM.MethodsAn analysis based on 16S rRNA microarray was performed on fecal samples obtained from 30 women with GDM and 28 healthy pregnant women.ResultsWe found 54 and 141 differentially abundant taxa between GDM and control group at the genus and the species level respectively. Among GDM patients, Peptostreptococcus anaerobius was inversely correlated with fasting glucose while certain species (e.g., Aureimonas altamirensis, Kosakonia cowanii) were positively correlated with fasting glucose.ConclusionsThis study suggests that there are large amounts of differentially abundant taxa between GDM and control group at the genus and the species level. Some of these taxa were correlated with blood glucose level and might be used as biomarkers for diagnoses and therapeutic targets for probiotics or synbiotics.
Highlights
Gestational diabetes mellitus (GDM) is defined as a glucose intolerance resulting in hyperglycemia of variable severity during pregnancy [1, 2]
Bacterial species with differential abundance At the genus level, we found 54 genera with differential abundance between GDM and control group (Additional file 1), including 42 genera depleted in GDM (e.g., Prevotella and Romboutsia) (Fig. 3a)
Species correlated with glucose tolerance in GDM To further understand the relationship between gut microbiome and GDM, we evaluated the correlations between the differentially abundant taxa and clinical traits
Summary
We found 54 and 141 differentially abundant taxa between GDM and control group at the genus and the species level respectively. Among GDM patients, Peptostreptococcus anaerobius was inversely correlated with fasting glucose while certain species (e.g., Aureimonas altamirensis, Kosakonia cowanii) were positively correlated with fasting glucose
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