Abstract
Noise induced hearing loss (NIHL), a multifactorial disease involving both genetic and environmental factors, is one of the most important occupational health hazards. Nonetheless, the influence of FOXO3 variants on NIHL risk have not been illuminated. This research was conducted to explore the effects of FOXO3 polymorphisms on individual susceptibility to NIHL. A total of 2689 industrial workers from one textile factory of east China were recruited to participate in the current research. Venous blood was collected, questionnaire and pure-tone audiometry (PTA) was conducted by specialist physicians. Then, we performed genotyping of three selected SNPs (rs2802292, rs10457180, and rs12206094) in FOXO3 gene in 566 NIHL patients and 566 controls. Subsequently, the main effects of genotype and its interactions were evaluated. Our results revealed that individuals with the G allele of rs2802292, G allele of rs10457180, T allele of rs12206094 (OR = 1.43, 1.43, and 1.31 respectively) and the haplotype GAC and others (TGT/GGT/GGC/GAT) (rs2802292-rs10457180-rs12206094) (OR = 1.49 and 2.09 respectively) are associated with an increased risk of NIHL in a Chinese population. Stratified analysis showed that an increased NIHL risk was found in the subjects who exposed to noise >16 years with rs2802292 GG/GT and rs10457180 AG/GG genotype with an OR of 1.62 and 1.66 respectively. Multifactor dimensionality reduction analysis indicated that rs10457180, rs2802292, and rs12206094 have interactions and are related to increased NIHL risk (OR = 1.53). The genetic polymorphism rs2802292, rs10457180, and rs12206094 within FOXO3 gene are associated with an increased risk of NIHL in a Chinese population and have potential to be biomarkers for noise exposed workers.
Highlights
Occupational noise is one of the most common occupational hazards for the health of industrial workers, and noise induced hearing loss (NIHL) is the second most frequent form of sensorineural hearing impairment besides age-related hearing loss (ARHL) worldwide[1]
NIHL and Forkhead Box O3 (FOXO3) polymorphism been verified that NIHL is a kind of multifactorial disease resulting from the interactions of both genetic and environmental factors[2]
Previous studies have found that single nucleotide polymorphism (SNPs) in HSP70, EYA4, CDH23, GRHL2 and DFNA5 genes are associated with human genetic susceptibility to NIHL and could increase or decrease the risk of NIHL by interaction with occupational noise[9,10,11]
Summary
Occupational noise is one of the most common occupational hazards for the health of industrial workers, and noise induced hearing loss (NIHL) is the second most frequent form of sensorineural hearing impairment besides age-related hearing loss (ARHL) worldwide[1]. Previous studies have found that single nucleotide polymorphism (SNPs) in HSP70, EYA4, CDH23, GRHL2 and DFNA5 genes are associated with human genetic susceptibility to NIHL and could increase or decrease the risk of NIHL by interaction with occupational noise[9,10,11].
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