Abstract
BackgroundSingle nucleotide polymorphisms (SNPs) located in the vascular endothelial growth factor (VEGF) gene may be correlated with the susceptibility to coronary artery disease (CAD) – although results have been controversial. The aim of this meta–analysis is to clarify the effects of VEGF –2578A/C (rs699947), −1154G/A (rs1570360), +405C/G (rs2010963), and + 936C/T (rs3025039) polymorphisms on CAD risk.MethodsPooled odds ratio (OR) and corresponding 95% confidence intervals (CIs) were calculated to estimate the strength of the association between VEGF gene polymorphisms and CAD risk. Fixed- or random-effects model was used depending on the heterogeneity between studies.ResultsIn total, 13 eligible articles containing 29 studies were analysed. The pooled analysis indicated that the VEGF gene polymorphisms of rs699947, rs2010963, and rs3025039 were associated with an increased risk of CAD, whereas no significant associations were observed with the rs1570360 polymorphism. A subgroup analysis stratified by ethnicity revealed that the rs699947 and rs3025039 polymorphisms were associated with CAD risk in Asian populations. In addition, stratification by control source indicated an increased risk of CAD susceptibility with the rs699947 polymorphism for population–based studies of reduced heterogeneity.ConclusionsIn summary, we concluded that the VEGF gene polymorphisms rs699947, rs2010963, and rs3025039 are correlated with an elevated CAD risk.
Highlights
Single nucleotide polymorphisms (SNPs) located in the vascular endothelial growth factor (VEGF) gene may be correlated with the susceptibility to coronary artery disease (CAD) – results have been controversial
Inclusion and exclusion criteria Eligible studies in our meta–analysis complied with the following criteria: 1) case–control studies evaluating VEGF gene polymorphisms and CAD susceptibility; 2) all CAD cases were documented by angiographic evidence showing at least 50% stenosis of one major coronary artery, myocardial infarction (MI), or coronary artery bypass surgery; 3) sufficient published data, such as the total number of cases and controls, distribution of genotypes, and other relevant information; and 4) language was restricted to English
915 were excluded due to duplicate records, 33 articles were determined to be ineligible after the screening of the titles and abstracts, and 20 articles were excluded after reading the full texts because of insufficient data, ineligible samples, or by virtue of being a review or conference abstract
Summary
Single nucleotide polymorphisms (SNPs) located in the vascular endothelial growth factor (VEGF) gene may be correlated with the susceptibility to coronary artery disease (CAD) – results have been controversial. The aim of this meta–analysis is to clarify the effects of VEGF –2578A/C (rs699947), −1154G/A (rs1570360), +405C/G (rs2010963), and + 936C/T (rs3025039) polymorphisms on CAD risk. The roles of endothelial dysfunction and angiogenesis in atherosclerosis development have been widely reported [3, 4]. Vascular endothelial growth factor (VEGF), an essential component of angiogenesis, has been reported to induce endothelial cell migration and proliferation, enhance vascular permeability, and modulate thrombogenicity [7,8,9].
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