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Abstract
AimIgA nephropathy (IgAN) is the major cause of end-stage renal disease(ESRD) in Asia and its pathogenesis is influenced by both genetic and environmental factors. Single nucleotide polymorphisms (SNPs) in IL1R1 and IL-1R2 may be associated with susceptibility to IgAN. In this study, we study the association between genetic variants of IL-1R1 and IL-1R2 and IgA nephropathy risk in the Chinese Han population.ResultIn the allelic model analysis, the rs10490571 and rs3917225 were associated with a 1.40-fold, and 1.31-fold increased risk of IgA nephropathy, respectively. In the genetic model analysis, the rs10490571 in IL1R1 was associated with a 1.46-fold increased risk of IgAN in the dominant model and 1.36-fold increased risk in the Log-additive model, respectively. However, the rs3218977 in IL1R2 was associated with a 0.71-fold decrease risk of IgAN in the dominant model and a 0.71–fold decrease risk in the over-dominant model, respectively. We found four SNPs (rs11674595, rs4851521, rs719250, and rs3218896) constructed four haplotypes in the IL1R2 gene and none of the haplotype was significantly associated with risk of IgAN.Materials and MethodsA case-control study was conducted including 426 nephropathy patients and 463 healthy controls. Chi-squared tests and genetic model were used to evaluate associations.>ConclusionsThese findings suggested that IL-1R1 and IL-1R2 polymorphisms may contribute to the development of IgAN.
Highlights
IgA nephropathy (IgAN), the most common primary glomerulonephritis in the world, is defined by the predominant IgAN deposition in the glomerular mesangium [1]
Chi-squared tests and genetic model were used to evaluate associations. These findings suggested that IL-1R1 and IL-1R2 polymorphisms may contribute to the development of IgAN
The disease mainly in the upper respiratory tract infection and the course of disease may be more severe in individuals of Asian ancestry [2]. the patients with IgAN, the mesangium IgA deposits are just because of the IgA1 subclass and often show with abnormal glycosylation [3, 4], which often accompany with an upper respiratory tract infection, and about 40% of these patients will develop into end-stage renal disease within the 20 years [5]
Summary
IgA nephropathy (IgAN), the most common primary glomerulonephritis in the world, is defined by the predominant IgAN deposition in the glomerular mesangium [1]. The disease mainly in the upper respiratory tract infection and the course of disease may be more severe in individuals of Asian ancestry [2]. The patients with IgAN, the mesangium IgA deposits are just because of the IgA1 subclass and often show with abnormal glycosylation [3, 4], which often accompany with an upper respiratory tract infection, and about 40% of these patients will develop into end-stage renal disease within the 20 years [5]. Several evidence support the genetic risk factors, containing differences in ethnic ,distributions in region, and individual variation in the course and prognosis of disease [7, 8]
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