Abstract
The research project outlines a new look at the concept of "inflammaging" and the role of the subclinical inflammatory process in various age-associated pathology, in particular coronary heart disease. Particular attention is paid to the tumor necrosis factor-α -cytokine, which plays an important role in the pathogenesis of chronic inflammatory processes and in the aging process. The increased content of tumor necrosis factor-α leads to the emergence and accumulation of various diseases, disability and mortality of elderly and senile people.
 Tumor necrosis factor-α influences various risk factors for cardiovascular pathology. This substance aggravates various breakdowns in metabolism, primarily causing insulin resistance. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (osteoporosis) and sarcopenia. Currently available data prove the important role of tumor necrosis factor-α in various age-associated pathologies.
Highlights
In Russia, "emergency medicine" is well developed - the treatment of a problem that is already clearly making itself felt in the form of symptoms and a burdened condition
The patterns and prognosis for patients of the older age group differ from younger groups, which means that each patient is considered as an independent clinical history
The prognosis of the course of coronary heart disease according to a set of clinical, instrumental, biochemical and genetic indicators is of great importance, as it allows you to make a personalized approach to each individual
Summary
In Russia, "emergency medicine" is well developed - the treatment of a problem that is already clearly making itself felt in the form of symptoms and a burdened condition. Coronary heart disease ( called coronary arterial disease or coronary atherosclerosis) is an independent nosological unit caused by absolute or relative insufficiency of coronary circulation, Coronary heart disease is the leading cause of death for both men and women worldwide (approximately 7 million people die annually). This is the collective name of a group of pathophysiologically related syndromes resulting from myocardial ischemia (an imbalance between perfusion and the need of the heart for oxygenated blood). The heart tolerates ischemia worse than isolated hypoxia, for example, with severe anemia, congenital heart disease of the blue type or long-term lung disease [1,2]
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