Association of Genetic Polymorphism of Insulin Receptor Substrate 1 (IRS-1) with Polycystic Ovary Syndrome Pathogenicity in Iraqi Women

Abstract

Background: Insulin receptor substrate 1 (IRS-1) is an intracellular signaling adapter protein that integratesand coordinates multiple biologically key extracellular signals within the cell, is also a key central receptorin insulin signaling, and plays a focal role in maintaining essential cellular capabilities, e.g., survival,development and digestion system. IRS1 is essentially found in the cytoplasm But localization in nucleusmay occur in some cell types and under certain stimuli.Materials and Method: A total of 104 healthy control and 215 Iraqi women have Polycystic ovary syndrome(PCOS) aged 20–40 years who was admitted to conducted a prospective clinical study at kerbala gynecologyteaching hospital, it was measured the genotype distribution of the rs2943641 T to C substitution of IRS1and the effects of genotypes on Polycystic Ovary syndrome Pathogenicity in Iraqiwomen,Results: Analyses were conducted to assess the association between the SNP rs2943641 [TT (Wild type),TC (heterozygous type), and CC (mutated type)], with the pathogenesis of PCOS according to logisticregression results. This survey demonstrated that there was no significant association between differentalleles for this SNP with the pathogenesis of PCOSConclusion: Genetic polymorphism with IRS-1may be associated with metabolic disturbance but notPolycystic Ovary syndrome in Iraqiwomen.