Abstract
Objectives. To study the association between proinflammatory cytokines and depression. Materials and methods. The: IL-1β C-511T and TNF-α G-308A gene polymorphisms were studied in patients with diagnoses of “depression” (study group) and mentally healthy subjects of comparable sex and age (controls). Results and conclusions. An association between the IL-1β C-511T polymorphism and depression was found, where the variant with the risk of depression was the CC variant (p = 0.001, OR = 1.9, CI 1.3–2.7). An association was found between the TNF-α G-308A polymorphism and depression, where the risk variant was the GG genotype (p = 0.001, OR = 3.0, CI = 1.8–4.9). These data confirm the role of immune factors in the development of depression. The authors emphasize the role of the clinical polymorphism of depression, which makes it difficult to form homogeneous cohorts and to select phenotypes for biological studies.
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