Abstract
Objectives: Dementia of the Alzheimer's type (DAT) is the most common chronic neurodegenerative disease. At present, the pathogenesis of DAT is not completely clear, and there are no drugs that can cure the disease. Once an individual is diagnosed with DAT, the survival time is only 3 to 9 years. Therefore, there is an urgent need to determine the etiology of DAT and the associated influencing factors to find a breakthrough in the treatment of DAT.Methods: We studied the relationship between polymorphisms in several genes (including BIN1 and APOE) and DAT susceptibility and the effects of sex differences on DAT. Our study included 137 patients with DAT and 509 healthy controls (HCs).Results: The APOE rs429358 polymorphism CC and CT genotypes were associated with an increased risk of DAT in women. We found a significant association between APOE ε4 and DAT. The frequency of the ε4 allele in the DAT group (15.5%) was higher than that in the HC group (8.7%). The BIN1 rs7561528 polymorphism was associated with a decreased risk of DAT in men.Conclusions: APOE gene rs429358 and BIN1 gene 7561528 genes may affect the susceptibility to DAT in a Chinese Han population.
Highlights
Dementia of the Alzheimer’s type (DAT) is the most common chronic neurodegenerative disease, affecting 44 million people worldwide, and is the fifth leading cause of death [1]
The Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR) scale were performed for all participants
The Bridging integrator 1 (BIN1) rs7561528 polymorphism was associated with a decreased risk of DAT in men
Summary
Dementia of the Alzheimer’s type (DAT) is the most common chronic neurodegenerative disease, affecting 44 million people worldwide, and is the fifth leading cause of death [1]. DAT is characterized by amyloid deposition in the hippocampus, early brain oxidative stress, and the development of nerve fiber tangles caused by the hyperphosphorylation of tau protein [4]. The result of these pathological changes is a series of clinical features, such as learning. Gene Polymorphisms of Dementia of Alzheimer’s Type and memory impairment, progressive aphasia, and decreased executive function [5]. Further understanding of DAT genetic susceptibility may be helpful for individual risk assessment and early intervention
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