Abstract
Introduction: Interleukin-16 (IL-16) is a chemotactic cytokine that is found to increase in Cancer and cardiovascular diseases (CVD). Single nucleotide polymorphisms (SNPs) in IL16 were associated with diseases. Thus, we conducted a systematic review and meta-analysis to evaluate possible associations between IL16 rs4778889, rs11556218, rs4072111, and rs1131445 SNPs and the risk for cancer or CVD.Materials and Methods: This study was performed according to the PRISMA statement. Medline, Web of Science, and Scopus databases were systematically reviewed, and a meta-analysis was conducted.Results: The analysis comprised 6386 individuals with cancer and 2415 with CVD. The SNP rs11556218 was significantly associated with an increased risk for cancer in Chinese in different genetic inheritance models. Also, to the best of our knowledge, this is the first meta-analysis to show an association of rs4778889 with an increased risk of gastric cancer and rs11556218 with an increased risk of CVD in Chinese.Conclusions: Our meta-analysis suggested that the SNPs rs11556218 and rs4778889 of IL16 were associated with an increased risk for cancer in Chinese and rs11556218 with increased risk for CVD in Chinese, highlighting the need for further studies on the impact of these polymorphisms on cancer treatment and surveillance.
Highlights
Interleukin-16 (IL-16) is a chemotactic cytokine that is found to increase in Cancer and cardiovascular diseases (CVD)
To the best of our knowledge, this is the first meta-analysis to show an association of rs4778889 with an increased risk of gastric cancer and rs11556218 with an increased risk of CVD in Chinese
Our meta-analysis suggested that the Single nucleotide polymorphism (SNP) rs11556218 and rs4778889 of IL16 were associated with an increased risk for cancer in Chinese and rs11556218 with increased risk for CVD in Chinese, highlighting the need for further studies on the impact of these polymorphisms on cancer treatment and surveillance
Summary
Interleukin-16 (IL-16) is a chemotactic cytokine that is found to increase in Cancer and cardiovascular diseases (CVD). Cancer is the second leading cause of morbidity and mortality worldwide. GLOBOCAN (Global cancer statistics) estimated for 2018 a total of 18.1 million people with cancer and 9.6 million deaths from this disease [1]. According to a 2019 USA estimate, the three most prevalent types of cancer among men were prostate cancer (3.65 million cases), colorectal cancer (776,000), and melanoma (684,000); among women, these were breast cancer (3.86 million), cervical cancer (807,000), and colorectal cancer (768,000) [2]. In China, 4.3 million new cases and approximately 2.8 million cancer deaths were estimated in 2015. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, with over 422.7 million estimated cases and 17.92 million deaths in 2015 alone. Coronary artery disease is the most prevalent CVD, followed by stroke [4]
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